{"id":"W2097069930","doi":"10.1042/bj20021630","title":"Processing of alpha4 integrin by the proprotein convertases: histidine at position P6 regulates cleavage","year":2003,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Montreal Clinical Research Institute","funders":"Medical Research Council; Canadian Institutes of Health Research; Medical Research Council Canada","keywords":"Furin; Proprotein Convertases; Proprotein convertase; Cleavage (geology); Chinese hamster ovary cell; Chemistry; Biochemistry; Mutant; Proteolysis; Molecular biology; Biology; Enzyme; Receptor; LDL receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000393204,0.0001305287,0.000219314,0.00005986257,0.0001229378,0.00002860565,0.0001428705,0.0001102734,0.0005107098],"category_scores_gemma":[0.000488166,0.00007768097,0.0001026615,0.0001861364,0.0002397758,0.00004091203,0.00005255146,0.0004899375,0.00002098059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002361686,"about_ca_system_score_gemma":0.0001615244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007093013,"about_ca_topic_score_gemma":2.908362e-7,"domain_scores_codex":[0.9985341,0.0001032726,0.0003635304,0.0001769829,0.0005623276,0.0002598118],"domain_scores_gemma":[0.9991645,0.00005085471,0.0001573956,0.0001848881,0.0002277365,0.000214626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002948569,0.0001575419,0.0003062823,0.00009580956,0.00002568853,0.00004279902,0.00004827823,1.201236e-7,0.9523625,0.00002668913,0.04471653,0.001922912],"study_design_scores_gemma":[0.0009329118,0.0002419495,0.0002252164,0.0001639018,0.00006389742,0.001613785,0.00009107202,0.00006873396,0.9914284,0.0001288444,0.004956707,0.00008455102],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933055,0.002835788,0.0002982508,0.002016605,0.00002846157,0.0003396887,0.000006569394,0.00001454804,0.001154612],"genre_scores_gemma":[0.9965162,0.00006530713,0.0009357785,0.0001982987,0.00006808515,0.00000801206,0.00001980765,0.00002118784,0.002167313],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03975983,"threshold_uncertainty_score":0.5591914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01389909291216844,"score_gpt":0.2789736120680804,"score_spread":0.2650745191559119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}