{"id":"W2097071802","doi":"10.1152/ajplung.90415.2008","title":"Role of HIF-1α in the regulation ACE and ACE2 expression in hypoxic human pulmonary artery smooth muscle cells","year":2009,"lang":"en","type":"article","venue":"American Journal of Physiology-Lung Cellular and Molecular Physiology","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":241,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Biological Sciences","funders":"","keywords":"Downregulation and upregulation; Hypoxia (environmental); Gene knockdown; Angiotensin-converting enzyme 2; Transcription factor; Pathogenesis; Hypoxia-inducible factors; Biology; Endocrinology; Internal medicine; Chemistry; Cell biology; Medicine; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002491681,0.0001905918,0.0006422429,0.0002677504,0.0000577347,0.000004794948,0.0001429247,0.0000858381,0.00001256825],"category_scores_gemma":[0.00002283033,0.0001281973,0.0001161786,0.0002639116,0.0003895158,0.0000801818,0.00005101079,0.0003473829,7.480785e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002232231,"about_ca_system_score_gemma":0.00004697998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003719411,"about_ca_topic_score_gemma":0.000001336886,"domain_scores_codex":[0.9983118,0.000484825,0.0004194862,0.0002821962,0.0001943917,0.0003073135],"domain_scores_gemma":[0.9991354,0.00009396301,0.000306182,0.000273807,0.00007352426,0.0001170927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005119054,0.000574904,0.0004748773,0.00002409265,0.00003332475,0.0003072721,0.0001967368,0.0000313512,0.9932218,0.00002922672,0.0000324158,0.004562095],"study_design_scores_gemma":[0.001415189,0.002560511,0.8017763,0.0001366004,0.0000587473,0.0001560479,0.0008394305,0.0004872617,0.1892054,0.003161497,0.00007902595,0.0001239801],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966159,0.002601285,0.00001283644,0.0004204926,0.00001961471,0.0002356152,0.000002430599,0.000003848112,0.00008800078],"genre_scores_gemma":[0.9987056,0.0004520376,0.0003449688,0.0004059655,0.00004634962,0.000004541002,0.00002095355,0.00001219782,0.000007335705],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8040164,"threshold_uncertainty_score":0.5227733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006304053511354127,"score_gpt":0.2496492610468871,"score_spread":0.243345207535533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}