{"id":"W2097091317","doi":"10.4049/jimmunol.177.7.4833","title":"Exposure of the Promonocytic Cell Line THP-1 to <i>Escherichia coli</i> Induces IFN-γ-Inducible Lysosomal Thiol Reductase Expression by Inflammatory Cytokines","year":2006,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Howard Hughes Medical Institute","keywords":"THP1 cell line; Biology; Cell biology; Secretion; Cytokine; Monocyte; Cell culture; Proinflammatory cytokine; Tumor necrosis factor alpha; Inflammation; Molecular biology; Biochemistry; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001567722,0.0003127741,0.0003518073,0.0001320165,0.0001743504,0.0003965975,0.0001379511,0.0002300542,0.0009931135],"category_scores_gemma":[0.00009630938,0.000170378,0.0002699611,0.0001719471,0.0001982745,0.0001459161,0.0001816509,0.0005935014,0.000615755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002786214,"about_ca_system_score_gemma":0.0002077004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004113517,"about_ca_topic_score_gemma":0.000568471,"domain_scores_codex":[0.9997609,0.00004938203,0.00002513972,0.00003971233,0.00004301542,0.00008181705],"domain_scores_gemma":[0.9998921,0.00002651573,0.00002709857,0.0000214505,0.00001402586,0.00001878533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001937647,0.00003295309,0.0002240964,0.00002820391,0.000003606631,0.00007751886,0.00002422622,0.00002766716,0.9988748,0.00004782152,0.00004925514,0.0004161224],"study_design_scores_gemma":[0.00002191229,0.0005330797,0.005366268,0.000008348866,0.00001375592,0.0002524285,0.00006834143,0.0004520559,0.9916366,0.00003717892,0.001604577,0.000005588761],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932296,0.001009168,0.002300104,0.0001335056,0.00008348498,0.00005032832,0.0008389638,0.00005583331,0.002298961],"genre_scores_gemma":[0.991744,0.001102074,0.003860577,0.0001743,0.00004379789,0.00006458916,0.001338306,0.00001938571,0.001653089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009931135,"threshold_uncertainty_score":0.003322244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008056481223062309,"score_gpt":0.2111232207631696,"score_spread":0.2030667395401073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}