{"id":"W2097098083","doi":"10.1261/rna.31506","title":"Probing the structure and function of an archaeal C/D-box methylation guide sRNA","year":2006,"lang":"en","type":"article","venue":"RNA","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Science Foundation","keywords":"Biology; Sulfolobus solfataricus; Methylation; Transfer RNA; Guide RNA; RNA; Small nucleolar RNA; Pseudouridine; Ribosomal RNA; Ribonucleoprotein; RNA methylation; Nucleic acid structure; Non-coding RNA; Genetics; Methyltransferase; Archaea; DNA; Genome; Gene; Cas9","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000138245,0.00006053832,0.00005504928,0.00001392337,0.00005672823,0.000009916613,0.00005836365,0.0000689117,0.00001106888],"category_scores_gemma":[0.00001399143,0.00004203397,0.00002186449,0.00002597985,0.00002549465,0.00000360759,0.0000237481,0.00003073281,3.637217e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002884623,"about_ca_system_score_gemma":0.00001337052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007570068,"about_ca_topic_score_gemma":0.00004184455,"domain_scores_codex":[0.9995707,0.00005450928,0.0001050286,0.0001253315,0.00006773631,0.00007670475],"domain_scores_gemma":[0.9997371,0.000005316243,0.00006346861,0.0001494016,0.00002922067,0.0000155295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002676239,0.000005218911,0.0001103147,0.00000707964,0.000008294083,1.528155e-7,0.00001937878,0.00006093316,0.9728138,0.0008132863,0.00004076748,0.02609402],"study_design_scores_gemma":[0.00008908923,0.0001198798,0.002743468,0.000004880657,0.00001310138,0.000003981528,0.00002253746,0.00005244357,0.9877729,0.004960331,0.004163936,0.00005341226],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928709,0.0004258537,0.005838621,0.00008084583,0.00005617768,0.0001217498,0.000006556242,0.000004866355,0.0005944815],"genre_scores_gemma":[0.9977379,0.00001555746,0.001696734,0.00003833398,0.0001971767,0.000003569326,0.00003573839,0.000007657354,0.0002673608],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02604061,"threshold_uncertainty_score":0.1714096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007256407447813748,"score_gpt":0.2271781462975811,"score_spread":0.2199217388497674,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}