{"id":"W2097099115","doi":"10.1038/nrd3591","title":"Designing antimicrobial peptides: form follows function","year":2011,"lang":"en","type":"review","venue":"Nature Reviews Drug Discovery","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":2014,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Deutsche Forschungsgemeinschaft; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Antimicrobial; Antibiotics; Antimicrobial peptides; Antibiotic resistance; Computational biology; Function (biology); Biology; Broad spectrum; Microbiology; Combinatorial chemistry; Chemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001025076,0.001754569,0.001783348,0.001114239,0.0002715486,0.001261322,0.001116658,0.001636495,0.001901458],"category_scores_gemma":[0.0009322176,0.000655117,0.0003612305,0.001540252,0.001021927,0.003005959,0.00109255,0.003158738,0.002133036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007967516,"about_ca_system_score_gemma":0.0008423955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003029067,"about_ca_topic_score_gemma":0.0005965337,"domain_scores_codex":[0.9997178,0.00003647757,0.00003154788,0.00004381226,0.0001345527,0.00003573459],"domain_scores_gemma":[0.9996581,0.0001439457,0.00006286541,0.00001694456,0.00007833276,0.00003975659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001150751,0.00009532033,0.00009486335,0.00732123,0.00004405342,0.0001847503,0.00003980832,0.001212357,0.01863382,0.0106266,0.0272343,0.9343978],"study_design_scores_gemma":[0.00006783329,0.0001951615,0.0001886432,0.001109178,0.00008514501,0.001030003,0.00003528989,0.0006459656,0.007253574,0.006095863,0.9832645,0.00002896338],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007014148,0.9883686,0.004809428,0.0009292277,0.0012664,0.00003056061,0.00003882558,0.00006312282,0.003792426],"genre_scores_gemma":[0.002953703,0.9888446,0.003870456,0.0008617894,0.0005608517,0.00003841524,0.00006304387,0.00001017653,0.002797003],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001901458,"threshold_uncertainty_score":0.006360948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02783727042511086,"score_gpt":0.2826010890361523,"score_spread":0.2547638186110414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}