{"id":"W2097112996","doi":"10.1158/1078-0432.ccr-11-0563","title":"Phase II Efficacy and Pharmacogenomic Study of Selumetinib (AZD6244; ARRY-142886) in Iodine-131 Refractory Papillary Thyroid Carcinoma with or without Follicular Elements","year":2012,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Thyroid Cancer Diagnosis and Treatment","field":"Medicine","cited_by":149,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute; U.S. Food and Drug Administration","keywords":"Follicular phase; Thyroid carcinoma; Medicine; Iodine; Refractory (planetary science); Selumetinib; Internal medicine; Oncology; Thyroid; Cancer; Biology; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001633293,0.00108263,0.001549117,0.0003231705,0.0002977054,0.0007235114,0.0007072418,0.000913033,0.001610092],"category_scores_gemma":[0.0007512541,0.0004535896,0.000871947,0.0003370582,0.0008579743,0.0006145519,0.0002358757,0.002033835,0.0004551623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008835441,"about_ca_system_score_gemma":0.001142944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006861397,"about_ca_topic_score_gemma":0.001485443,"domain_scores_codex":[0.999592,0.0002242844,0.0000196906,0.00005920996,0.0000467586,0.00005810772],"domain_scores_gemma":[0.9994778,0.0001034981,0.0001265067,0.00004679407,0.00003256444,0.0002129096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5801004,0.09514737,0.02133955,0.0008711638,0.002330537,0.000673972,0.0004075504,0.005400684,0.2016881,0.0003724733,0.002531411,0.08913685],"study_design_scores_gemma":[0.4226913,0.5379045,0.02053231,0.00002455167,0.0006321514,0.000618529,0.00007338173,0.002442182,0.0128809,0.000161567,0.002002556,0.00003608224],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977143,0.0006659561,0.0002577302,0.000124308,0.0000224367,0.0005400571,0.0002736803,0.00002268356,0.0003787768],"genre_scores_gemma":[0.9960039,0.0005325917,0.0007476981,0.0002723007,0.00005596663,0.0007778063,0.001052364,0.00001164702,0.000545733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001633293,"threshold_uncertainty_score":0.008637726,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2156758977380197,"score_gpt":0.5295338984641391,"score_spread":0.3138580007261195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}