{"id":"W2097112996","doi":"10.1158/1078-0432.ccr-11-0563","title":"Phase II Efficacy and Pharmacogenomic Study of Selumetinib (AZD6244; ARRY-142886) in Iodine-131 Refractory Papillary Thyroid Carcinoma with or without Follicular Elements","year":2012,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Thyroid Cancer Diagnosis and Treatment","field":"Medicine","cited_by":149,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute; U.S. Food and Drug Administration","keywords":"Follicular phase; Thyroid carcinoma; Medicine; Iodine; Refractory (planetary science); Selumetinib; Internal medicine; Oncology; Thyroid; Cancer; Biology; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002976697,0.0003225976,0.00106284,0.0002936655,0.0001871584,0.00002087485,0.0002307125,0.0001433034,0.0004144858],"category_scores_gemma":[0.0002436853,0.0002141619,0.0001049992,0.00063588,0.0003646091,0.0001445783,0.0002924874,0.0009359417,0.00001413899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003847794,"about_ca_system_score_gemma":0.0006439899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001203027,"about_ca_topic_score_gemma":0.0004058745,"domain_scores_codex":[0.9954801,0.0007078815,0.001098886,0.0007489077,0.001048785,0.0009154157],"domain_scores_gemma":[0.997311,0.0007467872,0.0002395279,0.0006841108,0.000289695,0.0007288565],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0170691,0.02949573,0.9218776,0.0001495444,0.0005909509,0.0002024195,0.001636753,0.000001637615,0.002561236,0.000003026487,0.001506625,0.02490543],"study_design_scores_gemma":[0.148273,0.06939892,0.7584519,0.0004721748,0.0007436631,0.00002797577,0.002192693,0.00006064859,0.004483963,0.000003782656,0.01545283,0.0004384233],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825687,0.01342346,7.819369e-7,0.0004379293,0.0001584586,0.003149309,0.00004335251,0.00002521808,0.0001927339],"genre_scores_gemma":[0.9918894,0.006009537,0.0001137614,0.0001870839,0.0005802469,0.0008082508,0.00001916535,0.00006886392,0.0003237024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1634256,"threshold_uncertainty_score":0.8733267,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2156758977380197,"score_gpt":0.5295338984641391,"score_spread":0.3138580007261195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}