{"id":"W2097127238","doi":"10.1002/anie.201500598","title":"Amphiphilic Tobramycins with Immunomodulatory Properties","year":2015,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Manitoba","funders":"Canadian Institutes of Health Research","keywords":"Lipopolysaccharide; Immune system; Innate immune system; Antibiotics; Septic shock; Bacteria; Microbiology; Amphiphile; Tumor necrosis factor alpha; Immunity; Chemistry; Biology; Sepsis; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007326266,0.0002081403,0.0001055722,0.000125603,0.00009395755,0.0001914078,0.00007392262,0.0002492133,0.0007214503],"category_scores_gemma":[0.0001407235,0.00004259024,0.0001207847,0.0001226214,0.0001239595,0.0001751751,0.0001925496,0.0002279853,0.0002317881],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001098439,"about_ca_system_score_gemma":0.0001179379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001370553,"about_ca_topic_score_gemma":0.0001868228,"domain_scores_codex":[0.9999386,0.0000169247,0.000004360963,0.000007985974,0.00001216095,0.00001985697],"domain_scores_gemma":[0.9999081,0.00001337677,0.00002768606,0.00001138202,0.00001218303,0.00002735573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005432319,0.000007816219,0.0001152372,0.00001893322,0.000001537277,0.00002896549,0.000004265773,0.00005451573,0.9978644,0.0001113643,0.00001778404,0.001720865],"study_design_scores_gemma":[0.00001181232,0.0002902015,0.001988074,0.000006860681,0.00000812926,0.0002710804,0.00001232648,0.0004094298,0.9917769,0.00007819381,0.005142594,0.000004228339],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915795,0.001787539,0.003955702,0.00009953453,0.00002245041,0.00002705798,0.0001911771,0.00005278023,0.002284198],"genre_scores_gemma":[0.996252,0.000586196,0.002308898,0.00004036554,0.000006705056,0.0000183466,0.00009159906,0.000006767099,0.0006891374],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007214503,"threshold_uncertainty_score":0.002413511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02589297334534531,"score_gpt":0.224292548471877,"score_spread":0.1983995751265317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}