{"id":"W2097172207","doi":"10.1091/mbc.e09-05-0397","title":"Oxidative Stress Inhibits Nuclear Protein Export by Multiple Mechanisms That Target FG Nucleoporins and Crm1","year":2009,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Emory University; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Nucleoporin; Biology; Nuclear export signal; Nuclear pore; Cell biology; Oxidative stress; Nuclear transport; Oxidative phosphorylation; Biochemistry; Cell nucleus; Cytoplasm","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008835489,0.0001909263,0.0001768354,0.00002707498,0.00009724667,0.00001033331,0.000232832,0.0002627837,0.00002303339],"category_scores_gemma":[0.00002993991,0.0001460697,0.0001009254,0.00005824693,0.0001499797,0.000004412652,0.0001505375,0.0001292997,0.000003241428],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007328386,"about_ca_system_score_gemma":0.00001642898,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001310545,"about_ca_topic_score_gemma":0.000002778412,"domain_scores_codex":[0.999058,0.0001002444,0.0001628272,0.0003712385,0.00008682306,0.0002208708],"domain_scores_gemma":[0.9993566,0.000003899479,0.0001571904,0.0003785474,0.00004352949,0.00006023717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007233123,0.0000626627,0.0003068735,0.000009461632,0.00002886054,0.00000142569,0.00004491334,0.000003794411,0.9977364,0.0005076155,0.0007120579,0.0005135841],"study_design_scores_gemma":[0.0004773168,0.0005523472,0.0005218826,0.0000101164,0.00001765967,0.000006238277,0.00008008943,0.0000188348,0.9886001,0.002092956,0.007455004,0.0001674183],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944431,0.0004818523,0.003142409,0.0002723335,0.0001106988,0.0003338114,0.00006160253,0.00001439681,0.001139788],"genre_scores_gemma":[0.996235,0.00002858837,0.002709892,0.0005578538,0.00003096693,0.000004785243,0.00008544855,0.00002348227,0.0003239603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009136283,"threshold_uncertainty_score":0.5956548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003770282578149992,"score_gpt":0.1931083869617542,"score_spread":0.1893381043836042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}