{"id":"W2097177732","doi":"10.1016/j.healun.2011.01.309","title":"302 Wnt3a Induces Myofibroblast Differentiation by Upregulating TGF-β Signaling through SMAD2 in a β-Catenin-Dependent Manner: Implications for Chronic Rejection","year":2011,"lang":"en","type":"article","venue":"The Journal of Heart and Lung Transplantation","topic":"Tissue Engineering and Regenerative Medicine","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"WNT3A; Wnt signaling pathway; Myofibroblast; Medicine; Transforming growth factor; Fibroblast; Cell biology; Signal transduction; Phenotype; Glycoprotein; Cancer research; Catenin; Immunology; Biology; Pathology; Internal medicine; In vitro; Genetics; Gene; Fibrosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002004704,0.0003296187,0.0002297581,0.0003638571,0.0002109009,0.0004427352,0.0001577108,0.0003458299,0.002354635],"category_scores_gemma":[0.00009959868,0.0002422846,0.0003848646,0.0001982816,0.0003460574,0.0002157173,0.0002411316,0.0007188945,0.0008825895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003282101,"about_ca_system_score_gemma":0.0004287188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001120948,"about_ca_topic_score_gemma":0.00246216,"domain_scores_codex":[0.9997923,0.00003597854,0.00002278337,0.00002070307,0.00005655725,0.00007169347],"domain_scores_gemma":[0.9998857,0.00001120961,0.00003438555,0.00001051364,0.00001194358,0.00004628384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003109861,0.00004198652,0.0002359301,0.00002723705,0.000005268266,0.00007679686,0.00001026139,0.00001746844,0.9986348,0.000100161,0.00004970162,0.000489386],"study_design_scores_gemma":[0.0001352524,0.0003016815,0.01023428,0.000009979963,0.00003362422,0.0004620551,0.00009990233,0.0006928435,0.9848604,0.0001187238,0.00304492,0.000006502935],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939104,0.001455557,0.001504047,0.0002407688,0.00004893753,0.00003957119,0.0003926173,0.00005554824,0.002352435],"genre_scores_gemma":[0.9928439,0.000827236,0.001079531,0.0001054008,0.00001481037,0.00004554039,0.0005364302,0.0000218436,0.004525306],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002354635,"threshold_uncertainty_score":0.007876992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0273450788324769,"score_gpt":0.2750864894903017,"score_spread":0.2477414106578248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}