{"id":"W2097181433","doi":"10.1038/tp.2013.73","title":"DNA methylation in interleukin-11 predicts clinical response to antidepressants in GENDEP","year":2013,"lang":"en","type":"article","venue":"Translational Psychiatry","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"H. Lundbeck A/S; European Commission; Medical Research Council; National Institute for Health and Care Research; Menzies Centre for Australian Studies, King's College London, University of London; GlaxoSmithKline","keywords":"Antidepressant; DNA methylation; Escitalopram; Nortriptyline; Major depressive disorder; CpG site; Epigenetics; Methylation; Medicine; Oncology; Pharmacology; Psychology; Bioinformatics; Clinical psychology; Internal medicine; Psychiatry; Biology; Genetics; Gene; Gene expression; Anxiety; Mood","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006116841,0.0001549865,0.0001945681,0.0003768266,0.00004114677,0.00003750126,0.0002676009,0.0001333062,0.0003512517],"category_scores_gemma":[0.0003477311,0.0001559822,0.00008687558,0.000612377,0.00006602395,0.0003598063,0.00002040972,0.0002525644,0.0002780248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001844389,"about_ca_system_score_gemma":0.0001328476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005084806,"about_ca_topic_score_gemma":0.0008046621,"domain_scores_codex":[0.9976686,0.0005143538,0.0006545826,0.0005231161,0.0003424926,0.0002969179],"domain_scores_gemma":[0.9989775,0.0005915001,0.00006676728,0.0002207443,0.00002113709,0.0001223154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002195262,0.001005464,0.8901359,0.00003633703,0.000007986643,0.00001048521,0.001626366,0.001708474,0.08439244,0.003495592,0.003205759,0.01217995],"study_design_scores_gemma":[0.00197175,0.00007278485,0.98447,0.0000461263,0.000001695685,0.000002709868,0.00006780127,0.001300229,0.001392921,0.009897752,0.0006032854,0.0001729216],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868901,0.00005632072,0.0006110898,0.009951939,0.0007150876,0.0006086539,0.00001944657,0.00005814542,0.001089243],"genre_scores_gemma":[0.9959738,0.000008295932,0.00166815,0.002082096,0.00009616562,0.00004402512,0.000005860207,0.00002042391,0.0001012045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09433413,"threshold_uncertainty_score":0.6360768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04721747153131118,"score_gpt":0.3380889343029776,"score_spread":0.2908714627716664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}