{"id":"W2097181433","doi":"10.1038/tp.2013.73","title":"DNA methylation in interleukin-11 predicts clinical response to antidepressants in GENDEP","year":2013,"lang":"en","type":"article","venue":"Translational Psychiatry","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"H. Lundbeck A/S; European Commission; Medical Research Council; National Institute for Health and Care Research; Menzies Centre for Australian Studies, King's College London, University of London; GlaxoSmithKline","keywords":"Antidepressant; DNA methylation; Escitalopram; Nortriptyline; Major depressive disorder; CpG site; Epigenetics; Methylation; Medicine; Oncology; Pharmacology; Psychology; Bioinformatics; Clinical psychology; Internal medicine; Psychiatry; Biology; Genetics; Gene; Gene expression; Anxiety; Mood","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002513806,0.0001909721,0.0002483866,0.0002563059,0.0001438331,0.00027325,0.0001417224,0.0003811402,0.001433526],"category_scores_gemma":[0.0008971868,0.0001282353,0.0002701459,0.0003689104,0.000127937,0.00008189457,0.0001825334,0.0003373816,0.0002272149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001161378,"about_ca_system_score_gemma":0.00008330103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00203837,"about_ca_topic_score_gemma":0.003706628,"domain_scores_codex":[0.9998587,0.00005105,0.00001427324,0.0000397028,0.00001615302,0.00001999332],"domain_scores_gemma":[0.9997098,0.0001021045,0.000101816,0.00002505462,0.00002634061,0.00003490226],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006553833,0.00003725905,0.9892777,0.00001481815,0.00008273917,0.0001003962,0.00006925523,0.00008689443,0.006417562,0.00001142545,0.0001151767,0.00313136],"study_design_scores_gemma":[0.00001449041,0.0000792051,0.9991128,0.000002786119,0.00003085717,0.0001511556,0.00002796468,0.0002011566,0.0002508561,0.0000139491,0.0001133777,0.000001327943],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993722,0.000163336,0.00007545757,0.0000302413,0.000003853527,0.00000305338,0.0002152682,0.000001911863,0.0001347156],"genre_scores_gemma":[0.9992243,0.00009186735,0.0001031083,0.00003624701,0.000004563058,0.000006223901,0.000336566,0.000001603169,0.0001956408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00203837,"threshold_uncertainty_score":0.004795611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04721747153131118,"score_gpt":0.3380889343029776,"score_spread":0.2908714627716664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}