{"id":"W2097275308","doi":"10.1093/molehr/gar005","title":"Wide-ranging DNA methylation differences of primary trophoblast cell populations and derived cell lines: implications and opportunities for understanding trophoblast function†","year":2011,"lang":"en","type":"article","venue":"Molecular Human Reproduction","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Queen's University; Wellcome Trust; Yale University","keywords":"DNA methylation; Biology; Trophoblast; Epigenetics; Methylation; Genetics; Gene; Cell biology; Gene expression; Placenta; Fetus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003812099,0.0002197731,0.0002586445,0.0004063389,0.0001497466,0.0003309787,0.0001777809,0.0002859497,0.0007981159],"category_scores_gemma":[0.0003994236,0.000174794,0.000197947,0.0002782251,0.0002788093,0.0001820471,0.0002195613,0.0004262097,0.0002441988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002221004,"about_ca_system_score_gemma":0.0001839936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001400009,"about_ca_topic_score_gemma":0.002367742,"domain_scores_codex":[0.9998579,0.00003573946,0.00001221208,0.00004719184,0.00002861118,0.00001833121],"domain_scores_gemma":[0.9997075,0.0001267781,0.00005786281,0.00005021027,0.00003240762,0.00002513459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004858211,0.000005228002,0.003324112,0.00004230841,0.000008308812,0.00003752882,0.0000653487,0.00004420588,0.9934609,0.0000579847,0.0000152644,0.002890212],"study_design_scores_gemma":[0.000006636819,0.0003024498,0.1913441,0.00002100075,0.00007173038,0.001129346,0.000275938,0.001192,0.7994704,0.0003165458,0.00585151,0.00001829827],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9501806,0.009509673,0.03540606,0.0002239769,0.00002795122,0.00008306216,0.002322887,0.0001814962,0.002064082],"genre_scores_gemma":[0.9741896,0.005127308,0.01685113,0.00008004451,0.00001352223,0.00009174959,0.002114379,0.00004537683,0.001486935],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001400009,"threshold_uncertainty_score":0.002783716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.125075948900514,"score_gpt":0.261505154437739,"score_spread":0.1364292055372251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}