{"id":"W2097292233","doi":"10.4049/jimmunol.177.10.6920","title":"Double-Negative T Cells, Activated by Xenoantigen, Lyse Autologous B and T Cells Using a Perforin/Granzyme-Dependent, Fas-Fas Ligand-Independent Pathway","year":2006,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Xenotransplantation and immune response","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Lawson Health Research Institute; Western University","funders":"","keywords":"Perforin; Granzyme B; Fas ligand; Granzyme; Cell biology; Chemistry; Apoptosis; Immunology; Molecular biology; Biology; Cytotoxic T cell; T cell; Programmed cell death; Immune system; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008014257,0.0002902321,0.0006350455,0.0002701497,0.0002696348,0.00003537878,0.0002494492,0.0002340422,0.0001024851],"category_scores_gemma":[0.00002717248,0.0001919698,0.0001486207,0.0002106122,0.0002965665,0.0001667493,0.00005542843,0.0008697087,0.00002247824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000129144,"about_ca_system_score_gemma":0.000283863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006382975,"about_ca_topic_score_gemma":0.0000209234,"domain_scores_codex":[0.9978387,0.0004445199,0.0007645373,0.000187026,0.0003378735,0.0004272978],"domain_scores_gemma":[0.9983882,0.000340042,0.0006534357,0.0002761067,0.0002506163,0.00009158932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009891497,0.0002682706,0.0002184682,0.00002867518,0.0004341341,0.0002118622,0.001510038,0.0001058151,0.9863411,0.00002773056,0.0002048911,0.0007575217],"study_design_scores_gemma":[0.007953618,0.001079125,0.003703225,0.0001186626,0.000378739,0.006159522,0.001040239,0.00009816546,0.9783421,0.00006262668,0.0008729097,0.0001911266],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931195,0.004426673,0.0006964384,0.000553412,0.0004790123,0.0003389382,0.00002006414,0.00003088475,0.0003351129],"genre_scores_gemma":[0.9957499,0.002485334,0.0002497967,0.0001496933,0.0000940117,0.000001948415,0.000006454931,0.00003843477,0.00122446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007999054,"threshold_uncertainty_score":0.7828303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01426043075140437,"score_gpt":0.2502695802190673,"score_spread":0.2360091494676629,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}