{"id":"W2097311750","doi":"10.1128/ec.05083-11","title":"Cellular Effects and Epistasis among Three Determinants of Adaptation in Experimental Populations of Saccharomyces cerevisiae","year":2011,"lang":"en","type":"article","venue":"Eukaryotic Cell","topic":"Evolution and Genetic Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Epistasis; Biology; Genetics; Saccharomyces cerevisiae; Allele; Gene; Mutation; Phenotype; Mutant; Evolutionary biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003689447,0.0003350363,0.000330468,0.0003709226,0.0002423215,0.0004011599,0.00041065,0.0003070939,0.0006450791],"category_scores_gemma":[0.0005443224,0.0002081731,0.0003504645,0.0002732138,0.0003429388,0.000104862,0.0005987204,0.0007777984,0.00007520624],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006103808,"about_ca_system_score_gemma":0.0002381002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00177653,"about_ca_topic_score_gemma":0.002891127,"domain_scores_codex":[0.9992927,0.0002198103,0.0001166817,0.0001414988,0.0001573974,0.00007191527],"domain_scores_gemma":[0.9994158,0.0001996609,0.000120291,0.00009362514,0.00005872779,0.000111872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002001408,0.00004645895,0.0008756833,0.00001707412,0.00001512516,0.00002496083,0.00002557465,0.00009857841,0.9980306,0.00008792178,0.00001011657,0.0005678366],"study_design_scores_gemma":[0.0001160253,0.0013385,0.05053812,0.000009330257,0.0001112597,0.0003322332,0.0001635762,0.006488427,0.9397705,0.0001876481,0.0009050538,0.00003938335],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984774,0.0001063017,0.0009972262,0.00002327129,0.000007707084,0.00001628549,0.0001024704,0.00001681463,0.0002525163],"genre_scores_gemma":[0.9977232,0.00007943738,0.001599186,0.00003412398,0.000004099407,0.00004532239,0.0002239672,0.00001446133,0.0002763422],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00177653,"threshold_uncertainty_score":0.004428625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02128116352893247,"score_gpt":0.2403885208980362,"score_spread":0.2191073573691037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}