{"id":"W2097321304","doi":"10.1095/biolreprod.106.051557","title":"Dynamic HIF1A Regulation During Human Placental Development1","year":2006,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":129,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; SickKids Foundation; Mount Sinai Hospital; University of Toronto","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"HIF1A; Biology; Oxygen tension; Syncytiotrophoblasts; Placentation; Cell biology; Hypoxia-inducible factors; Placenta; Endocrinology; Internal medicine; Cancer research; Biochemistry; Angiogenesis; Genetics; Fetus; Chemistry; Oxygen; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001842146,0.0001469225,0.0001561417,0.0003781969,0.0001661728,0.0004042789,0.0001277444,0.0001571327,0.0009149066],"category_scores_gemma":[0.0001651138,0.0001524566,0.0001192424,0.0002805871,0.0002088516,0.0001717501,0.0002232151,0.000263142,0.0002499984],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005291685,"about_ca_system_score_gemma":0.0001772087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001266545,"about_ca_topic_score_gemma":0.0008400676,"domain_scores_codex":[0.9998856,0.00001742303,0.000006586021,0.00003436795,0.00002693422,0.00002912292],"domain_scores_gemma":[0.9999253,0.00001513208,0.00002662016,0.000005465346,0.00001401447,0.00001353742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005474117,0.00002007821,0.004183391,0.00008602871,0.00000827538,0.0002224923,0.0001567172,0.0001300649,0.9862058,0.0002689984,0.0001985951,0.007972261],"study_design_scores_gemma":[0.00002791553,0.0005135812,0.1734274,0.00005081579,0.00004813015,0.001284284,0.0002536364,0.001389964,0.8029794,0.0004320056,0.01957568,0.00001707526],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9656424,0.02316424,0.005222367,0.0002435601,0.00003688159,0.00006431931,0.001583428,0.0001222009,0.003920624],"genre_scores_gemma":[0.9906149,0.004434991,0.001917526,0.00007860493,0.00002424473,0.00004149171,0.0008171407,0.00001889197,0.002052262],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001266545,"threshold_uncertainty_score":0.003839433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005473230789346117,"score_gpt":0.2360881209991249,"score_spread":0.2306148902097788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}