{"id":"W2097382536","doi":"10.1158/1535-7163.mct-10-0850","title":"Transcription Factor Stat5 Knockdown Enhances Androgen Receptor Degradation and Delays Castration-Resistant Prostate Cancer Progression <i>In vivo</i>","year":2011,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Cancer Institute; Deutsche Forschungsgemeinschaft","keywords":"Gene knockdown; LNCaP; Transactivation; Cancer research; Androgen receptor; Prostate cancer; STAT5; Androgen deprivation therapy; DU145; STAT protein; Biology; Transcription factor; Medicine; Apoptosis; Internal medicine; Cancer; Signal transduction; STAT3; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001120299,0.000257052,0.0002768468,0.0001360707,0.0001074683,0.0000414119,0.000075353,0.0001243694,0.0003358457],"category_scores_gemma":[0.000002992047,0.0002004268,0.00006619685,0.0002860753,0.0001293269,0.0001792343,0.00001610957,0.0002047223,0.000002921228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002806961,"about_ca_system_score_gemma":0.0003465331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006259538,"about_ca_topic_score_gemma":0.0006582588,"domain_scores_codex":[0.9983726,0.00008569308,0.0003145573,0.0004217705,0.0003940547,0.0004113657],"domain_scores_gemma":[0.9993767,0.0000120642,0.0001061189,0.0001963426,0.0001606743,0.0001481088],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00178858,0.0001573561,0.01470304,0.0001600267,0.0001909399,0.00004763159,0.003854341,0.00000315999,0.9109067,0.00003970504,0.00002973971,0.06811874],"study_design_scores_gemma":[0.002872458,0.0006519917,0.007127334,0.0003598887,0.0001616163,0.000006140493,0.000346373,0.0001605966,0.9826996,0.0001102282,0.005243535,0.0002602006],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.975067,0.02186496,0.0002197256,0.0008205742,0.0001638334,0.001321898,0.0002045295,0.00005104401,0.0002864054],"genre_scores_gemma":[0.9801375,0.01733501,0.0009266429,0.0003185533,0.00004388855,0.0005645003,0.00006192876,0.00004872503,0.000563273],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0717929,"threshold_uncertainty_score":0.8173168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05247718340301247,"score_gpt":0.3320901756609542,"score_spread":0.2796129922579417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}