{"id":"W2097384181","doi":"10.1128/iai.00572-08","title":"<i>Moraxella catarrhalis</i> Binding to Host Cellular Receptors Is Mediated by Sequence-Specific Determinants Not Conserved among All UspA1 Protein Variants","year":2008,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Pneumonia and Respiratory Infections","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; U.S. Public Health Service","keywords":"Moraxella catarrhalis; Biology; Bacterial adhesin; Fibronectin; Cell adhesion; Cell biology; Plasma protein binding; Microbiology; Receptor; Laminin; Binding protein; DNA-binding protein; Conserved sequence; Moraxella (Branhamella) catarrhalis; Integrin; Pilus; Cell adhesion molecule; Peptide sequence; Cell; Genetics; Haemophilus influenzae; Virulence; Gene; Extracellular matrix; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003295396,0.0002838894,0.0003862311,0.0002715344,0.0007500069,0.00005005742,0.00008530624,0.0002550877,0.0003016689],"category_scores_gemma":[0.0001681643,0.0002608667,0.0001035734,0.000538511,0.0002773929,0.0002386541,0.00006915928,0.0005257456,0.0002126238],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001366482,"about_ca_system_score_gemma":0.0001063098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003137078,"about_ca_topic_score_gemma":0.0001542581,"domain_scores_codex":[0.998359,0.0002350269,0.0004259435,0.0003574651,0.0002418469,0.0003807069],"domain_scores_gemma":[0.9988025,0.00006935441,0.000154986,0.0004061409,0.0001711418,0.0003958431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005492507,0.0001835641,0.1594187,0.00003541259,0.0000546393,0.00005340054,0.0006909943,4.676321e-7,0.8353019,0.00000155065,0.003952615,0.0002518868],"study_design_scores_gemma":[0.001824535,0.000760007,0.1911216,0.0002417095,0.0000779991,0.0004128093,0.0001314607,0.00006309315,0.6469121,0.000003356911,0.1579397,0.0005116261],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972625,0.00006215092,0.00005890105,0.0005371585,0.0005001256,0.000832546,0.00008506347,0.0001720247,0.0004895703],"genre_scores_gemma":[0.9965213,0.0005357289,0.00002078367,0.001433963,0.00008055631,0.0000772957,0.00009134164,0.00003548357,0.001203533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1883898,"threshold_uncertainty_score":0.9999844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05633661510716664,"score_gpt":0.275934078908312,"score_spread":0.2195974638011454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}