{"id":"W2097384181","doi":"10.1128/iai.00572-08","title":"<i>Moraxella catarrhalis</i> Binding to Host Cellular Receptors Is Mediated by Sequence-Specific Determinants Not Conserved among All UspA1 Protein Variants","year":2008,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Pneumonia and Respiratory Infections","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; U.S. Public Health Service","keywords":"Moraxella catarrhalis; Biology; Bacterial adhesin; Fibronectin; Cell adhesion; Cell biology; Plasma protein binding; Microbiology; Receptor; Laminin; Binding protein; DNA-binding protein; Conserved sequence; Moraxella (Branhamella) catarrhalis; Integrin; Pilus; Cell adhesion molecule; Peptide sequence; Cell; Genetics; Haemophilus influenzae; Virulence; Gene; Extracellular matrix; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001378547,0.0002466911,0.0001608123,0.0001753924,0.0001491459,0.0002605146,0.0001384417,0.0001557768,0.0005246369],"category_scores_gemma":[0.000252204,0.00009198205,0.0002601108,0.0001011278,0.0001488172,0.00009731416,0.0001541242,0.0001407813,0.0002158597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002375109,"about_ca_system_score_gemma":0.0001025264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001493038,"about_ca_topic_score_gemma":0.001601871,"domain_scores_codex":[0.9998488,0.00002798966,0.00001232626,0.00002224934,0.00004605956,0.00004267034],"domain_scores_gemma":[0.9998714,0.00001874371,0.00005293564,0.00001826309,0.00002025245,0.00001840788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003849095,0.00001120958,0.002129379,0.0000197406,0.000004342585,0.0000587816,0.0000199165,0.00002655877,0.9966843,0.00004313266,0.00002502577,0.0009390783],"study_design_scores_gemma":[0.00000538235,0.0002995049,0.08194597,0.00001069226,0.00002011077,0.001774727,0.00008944418,0.001053743,0.9119493,0.0000520963,0.00279148,0.000007445508],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986022,0.0004077895,0.0004673355,0.00002541589,0.000002687643,0.000004805098,0.0000920201,0.00001375553,0.0003839286],"genre_scores_gemma":[0.9982742,0.0001858168,0.0009253611,0.00002101952,0.000002971611,0.000005527414,0.0002924363,0.000004441478,0.0002882674],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001493038,"threshold_uncertainty_score":0.002968669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05633661510716664,"score_gpt":0.275934078908312,"score_spread":0.2195974638011454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}