{"id":"W2097398649","doi":"10.1111/nan.12084","title":"Phosphorylation of tau protein at sites <scp>Ser</scp><sup>396–404</sup> is one of the earliest events in <scp>A</scp>lzheimer's disease and <scp>D</scp>own syndrome","year":2013,"lang":"en","type":"article","venue":"Neuropathology and Applied Neurobiology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":276,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Douglas Mental Health University Institute","funders":"National Center for Research Resources; National Institute on Minority Health and Health Disparities; Canadian Institutes of Health Research","keywords":"Phosphorylation; Tau protein; Neurofibrillary tangle; Alzheimer's disease; Pathogenesis; Immunohistochemistry; Molecular biology; Pathology; Biology; Chemistry; Cell biology; Senile plaques; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001166452,0.000560834,0.0001924184,0.0007621236,0.0002750913,0.0002612922,0.0001614042,0.000301098,0.001980419],"category_scores_gemma":[0.0001199108,0.0001408274,0.0002371342,0.0003186599,0.0004262331,0.0002979729,0.0002408357,0.0002902967,0.0006271665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000282829,"about_ca_system_score_gemma":0.0001410757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005831923,"about_ca_topic_score_gemma":0.0005685998,"domain_scores_codex":[0.9999129,0.000007646643,0.0000109723,0.00002352589,0.00002783455,0.00001715655],"domain_scores_gemma":[0.9998387,0.00001315524,0.00008243002,0.000008130113,0.00001874124,0.00003877148],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003116441,0.00002213531,0.007185179,0.00008626319,0.0000202202,0.001138703,0.00004834143,0.00002836874,0.9882384,0.00005613927,0.0000570452,0.002807601],"study_design_scores_gemma":[0.00002395924,0.0005679849,0.2890331,0.00002301227,0.0000689648,0.01416711,0.0001448319,0.0002580299,0.6923223,0.000272272,0.003103437,0.00001501315],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966518,0.001500627,0.000484308,0.00003301751,0.000008936922,0.000009604913,0.0001921906,0.00002927209,0.001090149],"genre_scores_gemma":[0.9962464,0.001342124,0.0008791515,0.00001965954,0.00001820198,0.00001544176,0.0004136554,0.00001020308,0.001055143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001980419,"threshold_uncertainty_score":0.006625175,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01637330784026401,"score_gpt":0.2377848215187728,"score_spread":0.2214115136785088,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}