{"id":"W2097416376","doi":"10.4161/cc.6.16.4549","title":"Estrogen-Induced Rat Breast Carcinogenesis is Characterized by Alterations in DNA Methylation, Histone Modifications, and Aberrant microRNA Expression","year":2007,"lang":"en","type":"article","venue":"Cell Cycle","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":142,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"","keywords":"Carcinogenesis; Biology; DNA methylation; Epigenetics; Cancer research; Breast cancer; Cancer; microRNA; Histone; Pathology; Gene expression; Medicine; Genetics; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002705966,0.0001493814,0.000134929,0.00007664783,0.0001262792,0.00002954403,0.00008914344,0.0001542621,0.00001835846],"category_scores_gemma":[0.00001073471,0.0001573305,0.00004557359,0.0001080198,0.00003315127,0.00001004589,0.00004133764,0.00006624001,0.000005579487],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002833831,"about_ca_system_score_gemma":0.00003450947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005835135,"about_ca_topic_score_gemma":0.00002363723,"domain_scores_codex":[0.9989357,0.00006094116,0.0003186888,0.0003682128,0.0001035365,0.0002129015],"domain_scores_gemma":[0.9993982,0.00001706309,0.0001180398,0.0002848225,0.00007674273,0.000105178],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000489782,0.00008479119,0.001788573,0.00001141378,0.000005018794,7.298414e-7,0.0001744349,0.000008225586,0.9945093,0.000007737391,0.00008102054,0.00327978],"study_design_scores_gemma":[0.0005969015,0.00003745228,0.01397253,0.000006537494,0.00001169429,0.000002643282,0.00005437008,0.0000794655,0.9813485,0.00004252524,0.003674556,0.0001728839],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887444,0.004566419,0.005833501,0.0001272795,0.00007845737,0.0002764965,0.00004674971,0.000009413247,0.0003172887],"genre_scores_gemma":[0.99778,0.0004176546,0.0008913191,0.0000843539,0.00008897065,0.0000232019,0.0003672391,0.00002335331,0.0003238836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01316086,"threshold_uncertainty_score":0.6415751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01082201486575493,"score_gpt":0.2586230297479282,"score_spread":0.2478010148821733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}