{"id":"W2097416376","doi":"10.4161/cc.6.16.4549","title":"Estrogen-Induced Rat Breast Carcinogenesis is Characterized by Alterations in DNA Methylation, Histone Modifications, and Aberrant microRNA Expression","year":2007,"lang":"en","type":"article","venue":"Cell Cycle","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":142,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"","keywords":"Carcinogenesis; Biology; DNA methylation; Epigenetics; Cancer research; Breast cancer; Cancer; microRNA; Histone; Pathology; Gene expression; Medicine; Genetics; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001405908,0.0004183115,0.0003470677,0.0007215088,0.0001963423,0.00017567,0.0001857468,0.0002030628,0.002303769],"category_scores_gemma":[0.00007189275,0.0002571594,0.0003468349,0.000343768,0.0003054654,0.0001323295,0.0002393445,0.0005507691,0.0007278849],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003016229,"about_ca_system_score_gemma":0.0003057742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001304226,"about_ca_topic_score_gemma":0.002654685,"domain_scores_codex":[0.9998744,0.00001568295,0.000009277087,0.00003891025,0.00003044698,0.00003139428],"domain_scores_gemma":[0.9998928,0.00001011455,0.00003661334,0.00002003985,0.00001246413,0.00002793792],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004636318,0.00008219218,0.001588103,0.0000447685,0.00001275124,0.00009122833,0.00003053564,0.00003938667,0.9948065,0.00009279045,0.00005987272,0.002688149],"study_design_scores_gemma":[0.00005077631,0.002331719,0.05049305,0.00002236137,0.0000705679,0.001250699,0.0001833236,0.0002612147,0.936031,0.0001618853,0.009124479,0.00001890927],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888188,0.003221622,0.003179706,0.0001254486,0.00005313247,0.0000667079,0.001808566,0.0001286106,0.00259727],"genre_scores_gemma":[0.963035,0.007489623,0.006467564,0.00015898,0.00002193532,0.0002293814,0.003941052,0.00006470561,0.01859177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002303769,"threshold_uncertainty_score":0.007706881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01082201486575493,"score_gpt":0.2586230297479282,"score_spread":0.2478010148821733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}