{"id":"W2097463362","doi":"10.1101/gad.1310805","title":"RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis","year":2005,"lang":"en","type":"article","venue":"Genes & Development","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":292,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"McGill University; Amgen","keywords":"RhoC; Biology; Cell biology; Stress fiber; Metastasis; Motility; Cell adhesion; Cancer research; Focal adhesion; Cell; Signal transduction; Cancer; RHOA; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000130046,0.0001279898,0.000113378,0.00003848673,0.0001892005,0.00004036544,0.00007165876,0.00005293588,0.00005333863],"category_scores_gemma":[0.00002111846,0.0001289315,0.00007518205,0.00003212518,0.00001104997,0.000007207926,0.00006122029,0.00001800674,0.000007808604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002262024,"about_ca_system_score_gemma":0.0001000061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004840311,"about_ca_topic_score_gemma":0.0000646698,"domain_scores_codex":[0.99921,0.000009275259,0.0002106337,0.0002976269,0.00007011914,0.0002023516],"domain_scores_gemma":[0.9996067,0.00001105278,0.00007060857,0.0001318946,0.0001204449,0.00005927006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008500523,0.00005953499,0.00005430226,0.00003560808,0.0001341585,2.38858e-7,0.00007775485,0.00001699854,0.9400542,0.0002079037,0.003502881,0.05577146],"study_design_scores_gemma":[0.0003024748,0.00004442127,0.00007151029,0.00000340193,0.00002842603,0.000005740718,0.00004732535,0.0003203794,0.6074523,0.00003153411,0.3915781,0.0001144083],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8867159,0.001679092,0.1101567,0.0004108539,0.0002668874,0.0005430142,0.0001115064,0.00001053793,0.0001055045],"genre_scores_gemma":[0.8950742,0.0006663401,0.09641275,0.001146569,0.0005614722,0.0006879885,0.0009032977,0.0000527198,0.0044946],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3880752,"threshold_uncertainty_score":0.5257676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01539486329926219,"score_gpt":0.2624939073504111,"score_spread":0.2470990440511489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}