{"id":"W2097468536","doi":"10.1073/pnas.1108416108","title":"Mania-like behavior induced by genetic dysfunction of the neuron-specific Na <sup>+</sup> ,K <sup>+</sup> -ATPase α3 sodium pump","year":2011,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":152,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; St. Michael's Hospital; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research; Lundbeckfonden","keywords":"Sodium pump; Mania; Sodium; Chemistry; Psychology; Bipolar disorder; Lithium (medication); Psychiatry; Ouabain; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007495501,0.0005022599,0.0002047483,0.0002396346,0.0001371877,0.0001645235,0.000100751,0.0001836929,0.001000125],"category_scores_gemma":[0.00007697863,0.0001658728,0.0001784354,0.0001012316,0.0003593911,0.00009692242,0.0002279181,0.000406484,0.0001607492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001970296,"about_ca_system_score_gemma":0.0001342872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000533862,"about_ca_topic_score_gemma":0.001294438,"domain_scores_codex":[0.9999394,0.00001230436,0.000007493639,0.00001308147,0.00001509003,0.00001249696],"domain_scores_gemma":[0.9999115,0.000004993672,0.00005009352,0.000007285941,0.00000404617,0.000022035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002673373,0.00003391612,0.00111159,0.00003142732,0.00002146947,0.0005787933,0.00002298226,0.00004719459,0.9957462,0.0002078843,0.0001043561,0.001826897],"study_design_scores_gemma":[0.0002752223,0.00449214,0.1837982,0.00005969387,0.0002274885,0.02325323,0.0002985464,0.002240609,0.7777194,0.00112157,0.006462099,0.00005173568],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963335,0.0007043053,0.001327679,0.0001061668,0.00002860723,0.00002866833,0.0002356211,0.0001429778,0.001092438],"genre_scores_gemma":[0.996815,0.0008284975,0.001011962,0.00007286019,0.00001001138,0.00001895873,0.0002238771,0.00001319137,0.001005697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001000125,"threshold_uncertainty_score":0.003345788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05232908218454245,"score_gpt":0.2719970801833165,"score_spread":0.2196679979987741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}