{"id":"W2097495458","doi":"10.4049/jimmunol.1003789","title":"<i>Escherichia coli</i> Heat-Labile Enterotoxin Promotes Protective Th17 Responses against Infection by Driving Innate IL-1 and IL-23 Production","year":2011,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"","keywords":"Inflammasome; Heat-labile enterotoxin; Enterotoxin; Adjuvant; Innate immune system; CD80; Pertussis toxin; Microbiology; CD86; MAPK/ERK pathway; Bordetella pertussis; Immunology; Chemistry; Biology; Immune system; Escherichia coli; Inflammation; T cell; Signal transduction; Cell biology; In vitro; CD40; Cytotoxic T cell; Biochemistry; G protein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001300252,0.0004557328,0.0002508345,0.0001768287,0.0001010606,0.0003216211,0.0001140474,0.0002354387,0.001666559],"category_scores_gemma":[0.00009499694,0.00008843674,0.0002469083,0.0001301165,0.0001986388,0.0001750343,0.0001457482,0.0006697515,0.0005479737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002059599,"about_ca_system_score_gemma":0.0001683579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002411976,"about_ca_topic_score_gemma":0.0003750789,"domain_scores_codex":[0.9998389,0.00003541484,0.00002168258,0.00002226336,0.00003794945,0.00004374225],"domain_scores_gemma":[0.9999049,0.000007559343,0.00004618473,0.0000107535,0.00001194341,0.00001880156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001880406,0.00003209533,0.000157386,0.00004920216,0.000003601371,0.00002455096,0.00000397622,0.00004052713,0.9983267,0.00005909555,0.0001126221,0.001002234],"study_design_scores_gemma":[0.00001941205,0.0004790148,0.002938065,0.00001265965,0.00001227299,0.0002038811,0.00001436783,0.0004003398,0.9929911,0.00003795842,0.002887771,0.000003074885],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986048,0.003035977,0.005427581,0.0005757603,0.0002070355,0.00007035819,0.0007858284,0.0003217034,0.003527827],"genre_scores_gemma":[0.9905037,0.001425891,0.003124021,0.000273032,0.00006321533,0.00004419468,0.0007163198,0.0000511031,0.00379854],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001666559,"threshold_uncertainty_score":0.00557518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01167764210422578,"score_gpt":0.2197540286171703,"score_spread":0.2080763865129446,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}