{"id":"W2097496703","doi":"10.1093/nar/gnh169","title":"A mammalian artificial chromosome engineering system (ACE System) applicable to biopharmaceutical protein production, transgenesis and gene-based cell therapy","year":2004,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":137,"is_retracted":false,"has_abstract":true,"ca_institutions":"D-Wave Systems (Canada)","funders":"Institute of Materials Research and Engineering","keywords":"Biology; Transgenesis; Biopharmaceutical; Gene; Bacterial artificial chromosome; Genetics; Computational biology; Chromosome; Genetic enhancement; Human artificial chromosome; Gene engineering; Biotechnology; Genome; Recombinant DNA; Reproductive technology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004258328,0.0006718183,0.0005646222,0.0006987599,0.0003670235,0.0006909536,0.0004736328,0.0007786289,0.001512323],"category_scores_gemma":[0.0004352192,0.0003375664,0.0004358617,0.0005476468,0.0004742631,0.0004921641,0.0005760572,0.00115121,0.001451071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002891496,"about_ca_system_score_gemma":0.000447704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003387468,"about_ca_topic_score_gemma":0.0004064638,"domain_scores_codex":[0.9995153,0.00007050585,0.00004275417,0.00008732221,0.0002487514,0.00003525936],"domain_scores_gemma":[0.9998145,0.00004036765,0.00004925219,0.00003796619,0.00002566844,0.00003243734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004191485,0.00002800376,0.0001303442,0.0001617652,0.00001295177,0.0001200905,0.00002021432,0.0001937524,0.9784834,0.001834419,0.0005268857,0.01844626],"study_design_scores_gemma":[0.00002564671,0.0003900118,0.001466551,0.00003355214,0.00005452109,0.003386217,0.0000116359,0.001869011,0.876684,0.0006292529,0.1154219,0.00002774499],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.1511865,0.0338308,0.7794479,0.0009387792,0.001010662,0.001764881,0.002522887,0.005284507,0.024013],"genre_scores_gemma":[0.4258443,0.03935573,0.4938959,0.0005592069,0.0002933155,0.001286213,0.00687103,0.00032762,0.03156675],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.001512323,"threshold_uncertainty_score":0.005059183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03977656147651,"score_gpt":0.3186536229641102,"score_spread":0.2788770614876002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}