{"id":"W2097532486","doi":"10.1074/jbc.m101305200","title":"Characterization of SH2D1A Missense Mutations Identified in X-linked Lymphoproliferative Disease Patients","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Western University; Mount Sinai Hospital","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Mutant; Missense mutation; Biology; Genetics; Mutation; Gene; Plasma protein binding; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001203473,0.0005636069,0.0003136733,0.0007783192,0.0002959997,0.000334695,0.0002561683,0.0007406966,0.001489351],"category_scores_gemma":[0.0003931473,0.0001511477,0.0002663999,0.0003908448,0.00023237,0.0001463252,0.0002462592,0.0002447891,0.0003345869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001624188,"about_ca_system_score_gemma":0.00009494423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005772422,"about_ca_topic_score_gemma":0.0004362799,"domain_scores_codex":[0.9998013,0.00001974121,0.00002928822,0.00006865525,0.00004658197,0.00003432093],"domain_scores_gemma":[0.9998301,0.00004344275,0.00005182441,0.000005500738,0.000016989,0.00005205429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001846749,0.0002929266,0.4078548,0.000146809,0.0001511064,0.08539838,0.001165094,0.0005781853,0.4828877,0.0002907733,0.0005323161,0.01885521],"study_design_scores_gemma":[0.0001556268,0.001308947,0.7642894,0.00004387977,0.0001902634,0.1673297,0.000568427,0.001424588,0.05977702,0.0001583125,0.004711412,0.00004248445],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992526,0.0001654999,0.00009629845,0.00002084686,0.000005030538,0.0000109975,0.0001711683,0.000006627897,0.0002709631],"genre_scores_gemma":[0.9991838,0.0001073903,0.0001641308,0.00002809238,0.000006289773,0.000007708566,0.0002614302,0.000004457251,0.0002365924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001489351,"threshold_uncertainty_score":0.004982352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0169073878582817,"score_gpt":0.2416070695083407,"score_spread":0.224699681650059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}