{"id":"W2097535416","doi":"10.1152/ajpregu.00092.2011","title":"Malonyl-CoA mediates leptin hypothalamic control of feeding independent of inhibition of CPT-1a","year":2011,"lang":"en","type":"article","venue":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Instituto de Salud Carlos III; Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale; University of Alberta; National Institute of Diabetes and Digestive and Kidney Diseases; Heart and Stroke Foundation of Canada","keywords":"Malonyl-CoA; Anorectic; Endocrinology; Leptin; Internal medicine; Arc (geometry); Carnitine O-palmitoyltransferase; Hypothalamus; Chemistry; Biology; Cerulenin; Beta oxidation; Lipid metabolism; Metabolism; Fatty acid synthase; Food intake; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001879988,0.0004086182,0.0003431801,0.0002680268,0.0001751739,0.0004945433,0.0003128985,0.0002115144,0.001728871],"category_scores_gemma":[0.0001646841,0.0002428466,0.0003145105,0.0001354479,0.0004064867,0.0003153705,0.0003267204,0.001025593,0.0004327734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006364229,"about_ca_system_score_gemma":0.0003031147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001227966,"about_ca_topic_score_gemma":0.001625118,"domain_scores_codex":[0.9997981,0.0000273427,0.00002124879,0.00004663441,0.00005347599,0.00005321075],"domain_scores_gemma":[0.9997612,0.00002916393,0.00007789637,0.00002680253,0.0000292103,0.00007570264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003390358,0.00002874914,0.0001245575,0.00004122761,0.000004792003,0.0000311248,0.00001364374,0.00003325646,0.9980553,0.0003229498,0.00004728419,0.0009580657],"study_design_scores_gemma":[0.0001007111,0.0004141052,0.01038788,0.00002385834,0.00002525662,0.0001908018,0.00006264391,0.001831501,0.9809384,0.000168294,0.005842907,0.00001357654],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847509,0.005172697,0.003653289,0.0004790023,0.0001890068,0.00006013337,0.0006546364,0.0001321657,0.004908231],"genre_scores_gemma":[0.9874479,0.002475485,0.003354315,0.0001851302,0.00005224731,0.00008110773,0.0006758198,0.00005803251,0.005669876],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001728871,"threshold_uncertainty_score":0.005783617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03733487859627975,"score_gpt":0.2683448526953252,"score_spread":0.2310099740990454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}