{"id":"W2097565956","doi":"10.1038/embor.2011.243","title":"ChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repair","year":2011,"lang":"en","type":"article","venue":"EMBO Reports","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"Canadian Institutes of Health Research; Fonds Québécois de la Recherche sur la Nature et les Technologies; Breast Cancer Campaign; Cancer Research UK; Wellcome Trust","keywords":"Chromatin; PALB2; RAD51; Biology; Homologous recombination; Genetics; DNA damage; DNA repair; DNA; Cell biology; Molecular biology; Gene; Mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004506028,0.0002307305,0.0002290563,0.00006974112,0.00008448445,0.00002171004,0.00009091231,0.0001830624,0.00007412407],"category_scores_gemma":[0.0002717611,0.0002114504,0.0001181961,0.00007578008,0.00009232588,0.00001056025,0.0002206482,0.00008540099,0.00001371281],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001488983,"about_ca_system_score_gemma":0.00004985127,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006081365,"about_ca_topic_score_gemma":0.0000270761,"domain_scores_codex":[0.998495,0.00003334001,0.0003533366,0.0006127377,0.0001848927,0.0003207168],"domain_scores_gemma":[0.998982,0.00001498977,0.000223664,0.0005798098,0.00005401452,0.0001455596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001960425,0.0000861907,0.01956763,0.00005670828,0.0001051912,0.0002437022,0.0006979747,4.75357e-7,0.9773425,0.00006193289,0.0006377646,0.001180291],"study_design_scores_gemma":[0.000259704,0.000217207,0.01738467,0.00003727189,0.00003116448,0.0008093498,0.0003194826,0.00002503998,0.9762511,0.0004499436,0.003887073,0.0003279886],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965266,0.000544431,0.0001811468,0.00002555614,0.0003506864,0.000258854,0.00001317408,0.0001252005,0.001974333],"genre_scores_gemma":[0.9942453,0.00007750426,0.004419613,0.00007149171,0.00009983524,0.00004411202,0.00008205806,0.0000349161,0.0009251658],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004238466,"threshold_uncertainty_score":0.8622696,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0227939144021027,"score_gpt":0.2237896153957495,"score_spread":0.2009957009936468,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}