{"id":"W2097584728","doi":"10.1038/embor.2008.19","title":"NEDD8 acts as a ‘molecular switch’ defining the functional selectivity of VHL","year":2008,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada","keywords":"Ubiquitin ligase; Ubiquitin; NEDD8; Cell biology; Function (biology); Fibronectin; Chemistry; Biology; Extracellular matrix; Cancer research; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000317778,0.0001270413,0.0001360438,0.00002348193,0.000147529,0.000008207477,0.00007894266,0.0001125979,0.00007089361],"category_scores_gemma":[0.0002865303,0.00009913161,0.0001225782,0.0001095633,0.00008914448,0.000003509364,0.00008679942,0.0001171042,0.00001171386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008857184,"about_ca_system_score_gemma":0.0002637496,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004493852,"about_ca_topic_score_gemma":0.000009254686,"domain_scores_codex":[0.9989713,0.00006351464,0.0002392753,0.000300315,0.0002272667,0.0001983229],"domain_scores_gemma":[0.9992,0.00001811108,0.0001993341,0.0004087169,0.0001116092,0.00006223355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000649478,0.00008225838,0.01872098,0.00001511768,0.00008486129,0.0003074381,0.0001176015,0.0001003613,0.9762232,0.0006859722,0.002774056,0.0008232082],"study_design_scores_gemma":[0.0001395317,0.0001672162,0.01554569,0.000009718248,0.00001493494,0.002655357,0.00001933078,0.000006600578,0.9481681,0.0006177666,0.0325182,0.0001375472],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9754505,0.0008725462,0.000773842,0.00012332,0.0001717503,0.0001603716,0.000002939337,0.00001585233,0.02242884],"genre_scores_gemma":[0.99854,0.000032697,0.0002460573,0.0003244351,0.0001194626,0.00003084105,0.00004578886,0.00001774963,0.0006430085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02974415,"threshold_uncertainty_score":0.404247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01308510116043263,"score_gpt":0.2325299553566551,"score_spread":0.2194448541962225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}