{"id":"W2097598963","doi":"10.1101/gad.1890410","title":"Precise temporal control of the eye regulatory gene <i>Pax6</i> via enhancer-binding site affinity","year":2010,"lang":"en","type":"article","venue":"Genes & Development","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Eye Institute; National Human Genome Research Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Enhancer; PAX6; Biology; Transcription factor; Binding site; Regulation of gene expression; Gene; Enhancer RNAs; Regulator; DNA binding site; Regulatory sequence; Cell biology; Gene expression; Genetics; Promoter","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002890579,0.0001840186,0.0001766229,0.00002475198,0.0001525102,0.00001654085,0.0003436259,0.0001648972,0.00002742489],"category_scores_gemma":[0.00001757587,0.0001490804,0.00009923102,0.00006861904,0.00008513343,0.000002759246,0.000224948,0.0001128425,0.00001474865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002358024,"about_ca_system_score_gemma":0.0002859344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007370342,"about_ca_topic_score_gemma":0.0001714515,"domain_scores_codex":[0.9988855,0.00003418373,0.0003470811,0.0002998404,0.0001799816,0.0002534185],"domain_scores_gemma":[0.9990952,0.000007112294,0.0002120937,0.0005138284,0.00009895064,0.0000728104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002504154,0.00004473253,0.02432976,0.00001649512,0.00005492764,5.32946e-7,0.00008074722,0.00009714107,0.9706177,0.000009659567,0.0001204186,0.004602876],"study_design_scores_gemma":[0.0004367214,0.00002579396,0.03575117,0.000007992764,0.00001618099,0.000005393817,0.00001033637,0.0001160729,0.9294607,0.00002044226,0.03395486,0.0001943416],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962308,0.0003469547,0.002243285,0.00004632316,0.0005934944,0.0002597788,0.00003949522,0.000008916853,0.0002309494],"genre_scores_gemma":[0.9913553,0.00006079476,0.007453839,0.00006812742,0.0001324505,0.00003252766,0.0001073681,0.00002475115,0.0007648244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04115697,"threshold_uncertainty_score":0.6079323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00360972999003098,"score_gpt":0.1974776969671406,"score_spread":0.1938679669771096,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}