{"id":"W2097612488","doi":"10.1210/jc.2004-0881","title":"Association of the Cytotoxic T Lymphocyte-Associated Antigen 4 Gene with Type 1 Diabetes: Evidence for Independent Effects of Two Polymorphisms on the Same Haplotype Block","year":2004,"lang":"en","type":"article","venue":"The Journal of Clinical Endocrinology & Metabolism","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"","keywords":"Linkage disequilibrium; Haplotype; Allele; Biology; Genetics; Promoter; Cytotoxic T cell; Gene; Jurkat cells; Genetic association; Genotype; Molecular biology; Single-nucleotide polymorphism; T cell; Gene expression; In vitro; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005706871,0.000301158,0.0003313942,0.000576704,0.0002399006,0.0003112739,0.0002745237,0.0003611422,0.002779752],"category_scores_gemma":[0.001508667,0.0002524954,0.0004073463,0.0004295953,0.0003503085,0.0001246408,0.0002788082,0.0005692713,0.000275834],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001532666,"about_ca_system_score_gemma":0.0001541533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009782545,"about_ca_topic_score_gemma":0.001025618,"domain_scores_codex":[0.9991247,0.0003349009,0.0000637231,0.0002329585,0.0001465047,0.00009727202],"domain_scores_gemma":[0.9981651,0.0008464092,0.0004841233,0.0002090563,0.00008131679,0.0002140137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004035061,0.0003582935,0.7465802,0.00005970777,0.000567571,0.001825794,0.0004187275,0.0002340226,0.2337013,0.0003569433,0.0001599874,0.01170231],"study_design_scores_gemma":[0.0001944267,0.0006698066,0.9869226,0.00002083498,0.000256046,0.003277564,0.00007777027,0.0009294889,0.007019611,0.0002377754,0.0003780083,0.00001604902],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991906,0.0001569217,0.0003719435,0.00002057683,0.00000506586,0.00000509895,0.00004171777,0.000004049172,0.0002039737],"genre_scores_gemma":[0.9991364,0.0001087634,0.0003973829,0.00002590355,0.00001462458,0.000009130235,0.0001073539,0.000007264313,0.0001932413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002779752,"threshold_uncertainty_score":0.009299219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02527960766638487,"score_gpt":0.3130228890164171,"score_spread":0.2877432813500322,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}