{"id":"W2097643211","doi":"10.1002/jps.23265","title":"Vorinostat with sustained exposure and high solubility in poly(ethylene glycol)‐b‐poly(dl‐lactic acid) micelle nanocarriers: Characterization and effects on pharmacokinetics in rat serum and urine","year":2012,"lang":"en","type":"article","venue":"Journal of Pharmaceutical Sciences","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"National Center for Research Resources; National Cancer Institute","keywords":"Vorinostat; Micelle; Chemistry; Pharmacokinetics; Nanocarriers; Bioavailability; Solubility; Ethylene glycol; Pharmacology; Nuclear chemistry; Chromatography; Aqueous solution; Organic chemistry; Drug delivery; Histone deacetylase; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002038283,0.000252564,0.0001983589,0.0002238078,0.0001693366,0.0002419233,0.0001558282,0.0002450219,0.000392093],"category_scores_gemma":[0.0002886552,0.0001717295,0.0002146651,0.0001672874,0.0002454163,0.0003306491,0.0001633038,0.0003484428,0.000183428],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003552716,"about_ca_system_score_gemma":0.0003662685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001117033,"about_ca_topic_score_gemma":0.001146056,"domain_scores_codex":[0.999881,0.00002084343,0.000009909437,0.00002991207,0.000032747,0.00002553647],"domain_scores_gemma":[0.999904,0.00002532661,0.0000277098,0.00001149307,0.00001459434,0.00001694447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002983448,0.00002022259,0.00007680571,0.00001708542,0.000005502256,0.00003698981,0.00001719077,0.0001487013,0.9966565,0.00005614245,0.00003728771,0.002629264],"study_design_scores_gemma":[0.0000199864,0.0003139474,0.0004067282,0.000001407365,0.00001212597,0.00006815395,0.000005233831,0.0007740041,0.9978613,0.00001751242,0.0005154719,0.000004071287],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990875,0.00159153,0.006308751,0.0001126547,0.00002786061,0.00004284863,0.0001630416,0.0001128319,0.0007655979],"genre_scores_gemma":[0.9949864,0.0006687865,0.002689234,0.00003944225,0.00001351451,0.00003913217,0.0001480172,0.00003787788,0.001377559],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001117033,"threshold_uncertainty_score":0.002577722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01330464785508827,"score_gpt":0.3119530453742115,"score_spread":0.2986483975191233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}