{"id":"W2097643798","doi":"10.2337/diabetes.55.01.06.db05-0954","title":"High-Density Haplotype Structure and Association Testing of the Insulin-Degrading Enzyme (<i>IDE</i>) Gene With Type 2 Diabetes in 4,206 People","year":2006,"lang":"en","type":"article","venue":"Diabetes","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université du Québec à Chicoutimi","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Novo Nordisk Fonden; Academy of Finland; Sanofi; Kowa Company; Wellcome Trust; Novo Nordisk; American Diabetes Association; Medical Research Council; Richard and Susan Smith Family Foundation; Diabetestutkimussäätiö; Rockefeller Brothers Fund; Bristol-Myers Squibb","keywords":"Haplotype; Type 2 diabetes; Single-nucleotide polymorphism; Linkage disequilibrium; Genetics; Biology; Insulin resistance; Genetic association; Candidate gene; Gene; Diabetes mellitus; Allele; Genotype; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002636987,0.0001208607,0.0002240003,0.00003063832,0.00007859867,0.00001180316,0.00009483867,0.0001644751,0.000002603061],"category_scores_gemma":[0.0006278225,0.00008960208,0.00002727562,0.0002339637,0.00004166309,0.00000393962,0.00007464617,0.00009917977,5.815358e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000030145,"about_ca_system_score_gemma":0.00004069378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003218346,"about_ca_topic_score_gemma":0.0009201302,"domain_scores_codex":[0.999105,0.0001109787,0.0002158734,0.0002190831,0.00009387594,0.0002552199],"domain_scores_gemma":[0.9993114,0.0001259744,0.0002350654,0.0001711004,0.0001339992,0.00002243373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000002636473,0.00001225144,0.7125822,0.000008096977,0.00002069087,5.801555e-8,0.0000118919,0.0005338121,0.2865124,0.00001297906,0.0001575523,0.0001454279],"study_design_scores_gemma":[0.000227511,0.00007846036,0.7865732,0.00001141565,0.00002107638,2.667584e-7,0.000009726498,0.0003017395,0.2120984,0.0005466387,0.00004261476,0.00008892813],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987774,0.0007831419,0.000008485904,0.0001543284,0.00009735432,0.0001120813,0.00002561606,0.000007431232,0.00003412446],"genre_scores_gemma":[0.9977569,0.00002090699,0.0018549,0.0001184781,0.0001115355,0.000004922745,0.00006572259,0.00001443226,0.0000522076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07441404,"threshold_uncertainty_score":0.3653867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004907609884810624,"score_gpt":0.188865902463639,"score_spread":0.1839582925788284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}