{"id":"W2097647974","doi":"10.1017/s146114571100109x","title":"The dopamine D2 receptor regulates Akt and GSK-3 via Dvl-3","year":2011,"lang":"en","type":"article","venue":"The International Journal of Neuropsychopharmacology","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Western University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Quinpirole; GSK-3; Protein kinase B; Raclopride; Wnt signaling pathway; Chemistry; PI3K/AKT/mTOR pathway; Endocrinology; Dopamine receptor D2; Internal medicine; AXIN2; Cell biology; Signal transduction; Dopamine; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009373035,0.0002541452,0.0001240359,0.0002062016,0.0002126839,0.0003513645,0.0001263006,0.0001556129,0.001602022],"category_scores_gemma":[0.00008019691,0.0001413216,0.0003897597,0.0001254914,0.0001674344,0.0001692285,0.0001563429,0.0004403023,0.00036014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004580764,"about_ca_system_score_gemma":0.0002590481,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001324026,"about_ca_topic_score_gemma":0.003991065,"domain_scores_codex":[0.9999015,0.00001461176,0.000009287838,0.00002347835,0.00002285105,0.00002813581],"domain_scores_gemma":[0.9999479,0.00000355226,0.0000220194,0.000004223162,0.000007741362,0.00001457181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000224073,0.00003227803,0.0008566175,0.00006471075,0.00001640913,0.0001116633,0.00002550905,0.00005199362,0.9965917,0.0003121966,0.0001355667,0.001577349],"study_design_scores_gemma":[0.00009469165,0.000302785,0.04185228,0.00002671227,0.00005510377,0.0007701744,0.0001768786,0.001354281,0.9450141,0.0002422768,0.01009582,0.00001491128],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987728,0.005095124,0.00172997,0.0003151963,0.00006757079,0.00002681221,0.0008299179,0.0000654537,0.004141821],"genre_scores_gemma":[0.9913954,0.002140546,0.001184035,0.0001451167,0.0000102388,0.00002526897,0.0007103134,0.00001442961,0.00437452],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001602022,"threshold_uncertainty_score":0.005359292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01544423108985157,"score_gpt":0.2698428384849193,"score_spread":0.2543986073950677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}