{"id":"W2097663232","doi":"10.2353/ajpath.2008.080103","title":"Gene Silencing of Complement C5a Receptor Using siRNA for Preventing Ischemia/Reperfusion Injury","year":2008,"lang":"en","type":"article","venue":"American Journal Of Pathology","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":106,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lawson Health Research Institute; London Health Sciences Centre; Western University","funders":"London Health Sciences Centre; Heart and Stroke Foundation of Canada","keywords":"Anaphylatoxin; Gene silencing; Medicine; Transplantation; Kidney; Pharmacology; Renal ischemia; Reperfusion injury; C5a receptor; Acute tubular necrosis; Ischemia; Acute kidney injury; Immunology; Complement system; Pathology; Biology; Internal medicine; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004472769,0.0006585273,0.0005511112,0.0005280252,0.0003934137,0.000495831,0.0005057057,0.0007481114,0.002116296],"category_scores_gemma":[0.0002533435,0.0003388431,0.0006372984,0.0002092146,0.000494981,0.0003631901,0.0002415393,0.001008755,0.0006201463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007192893,"about_ca_system_score_gemma":0.0006160074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00143947,"about_ca_topic_score_gemma":0.002245681,"domain_scores_codex":[0.9996521,0.00005521366,0.00004159141,0.00007845146,0.00007212615,0.0001004859],"domain_scores_gemma":[0.9998075,0.00004640822,0.00005042737,0.00002780798,0.00002802234,0.00003980768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008875111,0.00002154455,0.00002640819,0.00003137414,0.000007233235,0.00002903928,0.000008752732,0.00004335035,0.9988508,0.0001821079,0.00007549267,0.0006351873],"study_design_scores_gemma":[0.00002201862,0.000119308,0.0004163051,0.000003118574,0.00002817199,0.00007432709,0.000009404838,0.0008287746,0.9975438,0.00003257556,0.0009183454,0.000003870648],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9722364,0.003330376,0.0178517,0.0006910976,0.0002965958,0.0001419106,0.0006044005,0.0005554048,0.004292169],"genre_scores_gemma":[0.9854528,0.001095741,0.007677825,0.0001960754,0.00003404964,0.0001267773,0.0005069938,0.0000716591,0.004838035],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002116296,"threshold_uncertainty_score":0.00707972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03346541199251421,"score_gpt":0.3011844743331948,"score_spread":0.2677190623406805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}