{"id":"W2097663232","doi":"10.2353/ajpath.2008.080103","title":"Gene Silencing of Complement C5a Receptor Using siRNA for Preventing Ischemia/Reperfusion Injury","year":2008,"lang":"en","type":"article","venue":"American Journal Of Pathology","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":106,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lawson Health Research Institute; London Health Sciences Centre; Western University","funders":"London Health Sciences Centre; Heart and Stroke Foundation of Canada","keywords":"Anaphylatoxin; Gene silencing; Medicine; Transplantation; Kidney; Pharmacology; Renal ischemia; Reperfusion injury; C5a receptor; Acute tubular necrosis; Ischemia; Acute kidney injury; Immunology; Complement system; Pathology; Biology; Internal medicine; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006235345,0.0001691512,0.0006922638,0.0002109255,0.0001851482,0.000002615036,0.0002855382,0.00006010734,0.0003498362],"category_scores_gemma":[0.0001979732,0.0001540953,0.0002602469,0.0001484108,0.0004333056,0.00007283633,0.0001254467,0.0001734938,0.000007242649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008347949,"about_ca_system_score_gemma":0.000168212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003448275,"about_ca_topic_score_gemma":0.000001462198,"domain_scores_codex":[0.997952,0.0003774655,0.001045792,0.0002028161,0.0000729063,0.0003489776],"domain_scores_gemma":[0.997373,0.0002723411,0.001779645,0.000224169,0.0003112011,0.00003966646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003255806,0.0001520861,0.01484798,0.0000293282,0.0001372226,0.0000240512,0.0007800121,0.00003903496,0.9768868,0.00002166915,0.001135419,0.005620822],"study_design_scores_gemma":[0.001589306,0.002340008,0.001732023,0.0001752913,0.0001536582,0.002613307,0.002114816,0.00002061102,0.9874601,0.00004744614,0.001541761,0.0002116437],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994018,0.001008338,0.003898068,0.00005571191,0.000658108,0.0002367371,0.00008818773,0.00001097129,0.00002592208],"genre_scores_gemma":[0.9877818,0.00007129719,0.01186071,0.00007501038,0.0001171553,0.000007204794,0.00002258596,0.00002052011,0.00004371451],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01311596,"threshold_uncertainty_score":0.6283824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03346541199251421,"score_gpt":0.3011844743331948,"score_spread":0.2677190623406805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}