{"id":"W2097665802","doi":"10.1128/mcb.01630-06","title":"An Activating Mutation in <i>sos-1</i> Identifies Its Dbl Domain as a Critical Inhibitor of the Epidermal Growth Factor Receptor Pathway during <i>Caenorhabditis elegans</i> Vulval Development","year":2007,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; National Center for Research Resources; National Institute of General Medical Sciences; University of British Columbia; Howard Hughes Medical Institute","keywords":"Guanine nucleotide exchange factor; Biology; Caenorhabditis elegans; Cell biology; MAPK/ERK pathway; Signal transduction; Epidermal growth factor; GRB2; Mutation; Kinase; Epidermal growth factor receptor; Tyrosine kinase; Cancer research; Genetics; Receptor; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000428662,0.0002481817,0.0002427265,0.00007958151,0.0001530353,0.00002608315,0.0002432144,0.0002661393,0.00001460621],"category_scores_gemma":[0.0004203662,0.0002179344,0.00007937078,0.0001616821,0.0002252857,0.00001950492,0.0002061367,0.0001805364,0.000002299188],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002980252,"about_ca_system_score_gemma":0.0001141898,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005799405,"about_ca_topic_score_gemma":0.00004970114,"domain_scores_codex":[0.9981002,0.0002780589,0.0004944446,0.000517109,0.0001581619,0.0004520492],"domain_scores_gemma":[0.9993057,0.00004452463,0.0001454886,0.0002760904,0.0001159891,0.0001121769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001239492,0.00009200813,0.002319989,0.00007937258,0.00002596835,0.00003916251,0.0001878282,0.000002641392,0.9945756,0.001440629,0.000005389938,0.001107488],"study_design_scores_gemma":[0.0006222363,0.0002198569,0.003305648,0.00005253735,0.000006411823,0.00004022357,0.0001569443,0.000002100202,0.9943581,0.0003662809,0.0006136819,0.0002560256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889598,0.003793841,0.006504797,0.0001041995,0.0001831159,0.0003442391,0.00005639741,0.00001330806,0.00004029506],"genre_scores_gemma":[0.9978098,0.00002525093,0.00158604,0.0001809055,0.0001021461,0.00003578644,0.0002152877,0.00003120048,0.00001361721],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00884996,"threshold_uncertainty_score":0.8887107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005086033069519509,"score_gpt":0.2361549068740099,"score_spread":0.2310688738044904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}