{"id":"W2097688250","doi":"10.1113/jphysiol.2009.172155","title":"Store overload‐induced Ca<sup>2+</sup> release as a triggering mechanism for CPVT and MH episodes caused by mutations in <i>RYR</i> and <i>CASQ</i> genes","year":2009,"lang":"en","type":"review","venue":"The Journal of Physiology","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary; University of Toronto","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Catecholaminergic polymorphic ventricular tachycardia; Ryanodine receptor 2; Ryanodine receptor; Malignant hyperthermia; Calsequestrin; RYR1; Dantrolene; Internal medicine; Caffeine; Endocrinology; Sudden death; Medicine; Chemistry; Cardiology; Anesthesia; Calcium","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001712799,0.0005287023,0.0004712445,0.0006409456,0.0002637533,0.0003881773,0.0004292563,0.0008596338,0.001316779],"category_scores_gemma":[0.0002319083,0.0002768475,0.0006029627,0.0001953138,0.0004963994,0.0004340091,0.0006307708,0.0006843523,0.0003161507],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003105933,"about_ca_system_score_gemma":0.0001581642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000483211,"about_ca_topic_score_gemma":0.0004249304,"domain_scores_codex":[0.9998286,0.00001809626,0.00003123415,0.000033346,0.00005873048,0.00003001863],"domain_scores_gemma":[0.9998085,0.0000203111,0.00008320936,0.00001874947,0.00001650065,0.00005289089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006505658,0.00005339645,0.004645017,0.00011228,0.00004316097,0.01718475,0.0001118112,0.0001265707,0.9722127,0.0007574348,0.000444803,0.003657585],"study_design_scores_gemma":[0.0004828083,0.00141297,0.2088856,0.0001298267,0.0003953146,0.2487045,0.0003962582,0.007562682,0.5150781,0.003615055,0.01322404,0.0001128105],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9848223,0.004508586,0.007021272,0.0005993817,0.0001341008,0.000107127,0.0003574799,0.0002272858,0.002222541],"genre_scores_gemma":[0.9956408,0.001311213,0.001489811,0.0001598128,0.00004970202,0.00005026738,0.0003287653,0.00002673609,0.0009429008],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.001316779,"threshold_uncertainty_score":0.004405081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02125258597067059,"score_gpt":0.3058699304097743,"score_spread":0.2846173444391037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}