{"id":"W2097689786","doi":"10.1074/jbc.m110.159897","title":"Overlapping Binding Sites of Structurally Different Antiarrhythmics Flecainide and Propafenone in the Subunit Interface of Potassium Channel Kv2.1*","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Flecainide; Chemistry; Docking (animal); Xenopus; Homology modeling; Binding site; Helix (gastropod); Potassium channel; Propafenone; Biophysics; Protein subunit; Stereochemistry; Biochemistry; Biology; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001145306,0.0002887496,0.0003439398,0.0001069221,0.0001696814,0.00021578,0.0003035045,0.000415637,0.001261902],"category_scores_gemma":[0.0002479094,0.0001269665,0.0004169398,0.00007562241,0.0001974392,0.00027969,0.0002052618,0.0003483065,0.0002185715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003000274,"about_ca_system_score_gemma":0.0001769634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001097484,"about_ca_topic_score_gemma":0.001332407,"domain_scores_codex":[0.999874,0.00001852645,0.000008706666,0.00002913355,0.00003744381,0.00003218455],"domain_scores_gemma":[0.9998976,0.00002990749,0.00003261636,0.000005683706,0.00001247015,0.00002165112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007747292,0.00004305406,0.001603287,0.00006470914,0.00002670515,0.0004037699,0.0000371706,0.001672919,0.9921923,0.0005991093,0.0001045359,0.0024777],"study_design_scores_gemma":[0.0002715038,0.001042901,0.0455978,0.00003531804,0.0002373291,0.00247715,0.0001467462,0.04686703,0.8990715,0.0007389295,0.003461194,0.00005274521],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994173,0.0007449302,0.00359479,0.00005974507,0.00001752344,0.00001741316,0.0001029035,0.00002826338,0.001261439],"genre_scores_gemma":[0.9980438,0.000145096,0.001283274,0.00005217735,0.00000262035,0.00001040383,0.0001727337,0.000006395106,0.0002835004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001261902,"threshold_uncertainty_score":0.004221439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01927217524063086,"score_gpt":0.2599711732990613,"score_spread":0.2406989980584305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}