{"id":"W2097695105","doi":"10.1091/mbc.e11-02-0155","title":"Vacuolar H<sup>+</sup>-ATPase subunits Voa1 and Voa2 cooperatively regulate secretory vesicle acidification, transmitter uptake, and storage","year":2011,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"ATP Synthase and ATPases Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Exocytosis; Biology; Gene knockdown; Cell biology; Secretory Vesicle; Vesicle; Endosome; Golgi apparatus; Secretion; Biochemistry; Endoplasmic reticulum; Intracellular; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002519967,0.0002068236,0.0002038792,0.00004782264,0.0001425466,0.00001131033,0.0003055925,0.0002363287,0.00004211524],"category_scores_gemma":[0.00004839398,0.0001577057,0.00008651713,0.0001053532,0.0005785638,0.000007077214,0.0001933002,0.0001575352,0.000005061763],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006528018,"about_ca_system_score_gemma":0.00005573558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003281729,"about_ca_topic_score_gemma":0.000004164698,"domain_scores_codex":[0.9986838,0.0002596936,0.0002371849,0.0004417283,0.00009094951,0.0002866466],"domain_scores_gemma":[0.9991514,0.0000162746,0.00009007422,0.0005094245,0.0001204318,0.0001123918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001135706,0.00007148871,0.001403036,0.00003495656,0.00006748258,0.00000961989,0.0003624223,0.00001196962,0.9966971,0.0001296537,0.0002497353,0.0008490163],"study_design_scores_gemma":[0.0006251527,0.0002970311,0.00368685,0.00001160684,0.00003986821,0.00001299782,0.0001145038,0.0001751961,0.989701,0.0001696069,0.004977502,0.0001887054],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929106,0.003265275,0.002773044,0.0002218504,0.00002942857,0.0002859106,0.0000572327,0.000009075026,0.0004476088],"genre_scores_gemma":[0.9979045,0.0003114747,0.0006279711,0.000350052,0.00003290907,0.00001788147,0.00005365456,0.00002888791,0.0006727171],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00699607,"threshold_uncertainty_score":0.6431051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01741226710005444,"score_gpt":0.2412421379660093,"score_spread":0.2238298708659548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}