{"id":"W2097698114","doi":"10.1124/jpet.104.071977","title":"The Combi-Targeting Concept: Dissection of the Binary Mechanism of Action of the Combi-Triazene SMA41 in Vitro and Antitumor Activity in Vivo","year":2004,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Quinazolinone synthesis and applications","field":"Chemistry","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"Royal Victoria Hospital","funders":"","keywords":"Autophosphorylation; In vivo; A431 cells; Quinazoline; Epidermal growth factor receptor; Molecular biology; Chemistry; In vitro; Mechanism of action; Tyrosine kinase; Cancer research; Kinase; Biology; Biochemistry; Cell cycle; Signal transduction; Receptor; Protein kinase A; Stereochemistry; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002699389,0.00008823306,0.0002090025,0.00002983035,0.0001270214,0.000005021016,0.0001533624,0.00007038914,0.0000213327],"category_scores_gemma":[0.000005700919,0.00005180905,0.00007286062,0.0001046812,0.0002814863,0.00006541412,0.00006084605,0.0002585623,3.029999e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000617542,"about_ca_system_score_gemma":0.00004984798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002917676,"about_ca_topic_score_gemma":0.000005025912,"domain_scores_codex":[0.9992417,0.0001028253,0.0003648257,0.00007499943,0.0001140265,0.0001016171],"domain_scores_gemma":[0.9991748,0.0001467295,0.0005496148,0.00007714453,0.00003465317,0.00001706097],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000497633,0.0005160567,0.0006274247,0.00002056655,0.00005757681,7.070506e-7,0.0008581299,0.00006774741,0.9965578,0.0003627572,0.000004740242,0.0004288371],"study_design_scores_gemma":[0.001666597,0.00007712827,0.001625712,0.00003802601,0.00004653388,0.00002463697,0.002006768,0.0002174136,0.9936334,0.0005579834,0.00005935825,0.00004646652],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977713,0.001232437,0.00001251168,0.0006187016,0.0001976354,0.0001050492,0.000007719948,0.000001565555,0.00005314548],"genre_scores_gemma":[0.9993542,0.0005159094,0.00002780654,0.00004422029,0.00003672184,0.000005414828,1.838514e-7,0.000006608699,0.000008935092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002924446,"threshold_uncertainty_score":0.2112712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02141915927047101,"score_gpt":0.321222353934921,"score_spread":0.29980319466445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}