{"id":"W2097726306","doi":"10.1158/0008-5472.can-07-1528","title":"A <i>CDKN2A</i> Mutation in Familial Melanoma that Abrogates Binding of p16INK4a to CDK4 but not CDK6","year":2007,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"CDKN2A; p14arf; Cyclin-dependent kinase 6; Biology; Cancer research; Exon; Melanoma; Mutation; Genetics; Senescence; Molecular biology; Cell cycle; Gene; Tumor suppressor gene; Carcinogenesis; Cyclin-dependent kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001756043,0.0001582649,0.0003436922,0.001023378,0.00007670518,0.00002052706,0.0002058577,0.0001839323,0.0002223629],"category_scores_gemma":[0.0003870306,0.000157864,0.00008769531,0.001426739,0.0001616845,0.0000802527,0.0001217991,0.0006839202,0.00009668354],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001079429,"about_ca_system_score_gemma":0.0006284242,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00396286,"about_ca_topic_score_gemma":0.002794155,"domain_scores_codex":[0.9971191,0.0001016605,0.0003861533,0.000450139,0.001162345,0.0007806608],"domain_scores_gemma":[0.9986455,0.0002380659,0.00006751656,0.0003946325,0.0003573969,0.0002968578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001833681,0.00009953518,0.01018484,0.0001974776,0.00004809271,0.0004817874,0.00168735,0.0001128685,0.9644898,0.0001712243,0.0007773375,0.019916],"study_design_scores_gemma":[0.002604162,0.0005982795,0.02883955,0.0006479925,0.00002049911,0.00003486893,0.001104106,0.00005966482,0.9633119,0.0000508448,0.002569588,0.0001586208],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937997,0.0007879685,0.0002198045,0.0009361043,0.0002677164,0.001046696,0.00005124447,0.00003823985,0.002852463],"genre_scores_gemma":[0.9980364,0.0002014265,0.000343361,0.0002215364,0.000212443,0.000131929,0.00002564812,0.00005053031,0.0007767237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01975738,"threshold_uncertainty_score":0.6437508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08538413017698315,"score_gpt":0.4106412235089448,"score_spread":0.3252570933319616,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}