{"id":"W2097741655","doi":"10.1016/j.crohns.2014.05.007","title":"Crohn's disease outpatients treated with adalimumab have an earlier secondary loss of response and requirement for dose escalation compared to infliximab: A real life cohort study","year":2014,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"University of Alberta; Alberta Innovates; Alberta Innovates - Health Solutions","keywords":"Medicine; Infliximab; Adalimumab; Crohn's disease; De-escalation; Cohort; Internal medicine; Inflammatory bowel disease; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001586449,0.0004321461,0.0006080777,0.0006716237,0.0006726384,0.001225312,0.0003982598,0.000660756,0.001866543],"category_scores_gemma":[0.00346366,0.0004814411,0.0008398492,0.0005908571,0.0003310428,0.000901951,0.0004867917,0.001040537,0.0003744922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00049784,"about_ca_system_score_gemma":0.0004033435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001788022,"about_ca_topic_score_gemma":0.001688544,"domain_scores_codex":[0.9991246,0.000246681,0.00008381932,0.0002340106,0.0001450041,0.0001658792],"domain_scores_gemma":[0.9968656,0.0004942071,0.001427843,0.0003972882,0.0002383655,0.0005767472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002381917,0.0004469237,0.9941168,0.00001524157,0.0001288689,0.0002142473,0.0002540917,0.00003840377,0.0004853893,0.00001806488,0.0001243841,0.001775673],"study_design_scores_gemma":[0.0002274641,0.002430864,0.9946085,0.000008970283,0.0001057947,0.001260929,0.0003787437,0.0004136451,0.00020082,0.00002719051,0.0003208303,0.00001627658],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997059,0.00006362714,0.0000474177,0.0000145227,0.000004536573,0.00001096704,0.00006986356,0.000001784877,0.00008138858],"genre_scores_gemma":[0.999529,0.00004802483,0.00005704112,0.00002220327,0.00001148841,0.00001499262,0.000205586,0.000002231087,0.000109519],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001866543,"threshold_uncertainty_score":0.008390069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009976620233146105,"score_gpt":0.2623562512399987,"score_spread":0.2523796310068526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}