{"id":"W2097829021","doi":"10.3998/ark.5550190.0002.604","title":"Design and syntheses of 4-[3-(1-methoxycarbonyl-1,6-dihydropyridyl)]- and 4-[3-(1-methoxycarbonyl-4-substituted-1,4-dihydropyridyl)]- derivatives of alkyl 1,4-dihydro-2,6-dimethyl-3-nitro-5-pyridine-carboxylates with calcium channel modulating activities","year":2001,"lang":"en","type":"article","venue":"ARKIVOC","topic":"Synthesis and Reactivity of Heterocycles","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Nitro; Alkyl; Medicinal chemistry; Stereochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009756023,0.001020244,0.001832639,0.0004295376,0.0003738354,0.0001109751,0.0004916607,0.0004937494,0.00009785884],"category_scores_gemma":[0.0006063111,0.0008686364,0.0002597995,0.0004745208,0.001646009,0.00077897,0.0003430353,0.0005897668,0.000001283444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008052761,"about_ca_system_score_gemma":0.0001184335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007423571,"about_ca_topic_score_gemma":0.00003584475,"domain_scores_codex":[0.9954711,0.0003660599,0.001099816,0.001225171,0.0008328305,0.001005062],"domain_scores_gemma":[0.9936069,0.00409179,0.0008546132,0.0008970129,0.0001848237,0.0003648989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000761376,0.0003985141,0.009446459,0.0006909008,0.0008096679,0.00006205457,0.001928575,0.002233892,0.9656911,0.00009058625,0.00001035595,0.01787654],"study_design_scores_gemma":[0.001122293,0.0002736598,0.002086099,0.001322741,0.0004113039,0.0002523627,0.00215605,0.04565394,0.9445948,0.0008741598,0.0001693793,0.001083236],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852818,0.003871346,0.006314621,0.0001845915,0.00009905522,0.000445381,0.00004378834,0.0002160406,0.003543396],"genre_scores_gemma":[0.9854417,0.001261936,0.01272999,0.00003089107,0.0001797549,0.00007697313,0.00001122797,0.000177769,0.00008972164],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04342005,"threshold_uncertainty_score":0.9993764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03198061572833519,"score_gpt":0.247547540600951,"score_spread":0.2155669248726158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}