{"id":"W2097848666","doi":"10.1081/ddc-100103726","title":"Formulation and Physiological and Biopharmaceutical Issues in the Development of Oral Lipid-Based Drug Delivery Systems","year":2001,"lang":"en","type":"review","venue":"Drug Development and Industrial Pharmacy","topic":"Drug Solubulity and Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Biopharmaceutical; Bioavailability; Drug; Excipient; Chemistry; Pharmacology; First pass effect; Drug development; Drug delivery; Drug metabolism; Biotechnology; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.004142208,0.0008124358,0.001901405,0.0004237692,0.000489669,0.0001294666,0.0004337099,0.0006454773,0.00008249924],"category_scores_gemma":[0.00007765908,0.0005735156,0.0001408808,0.0005817151,0.0003461046,0.0002587423,0.0002771804,0.00169208,0.00002307857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001566127,"about_ca_system_score_gemma":0.000821023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001302924,"about_ca_topic_score_gemma":0.00003961288,"domain_scores_codex":[0.9940494,0.002033942,0.001975507,0.0007720495,0.0004357683,0.0007333221],"domain_scores_gemma":[0.997677,0.001063683,0.0006354338,0.0001927388,0.00009703411,0.0003341066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003796773,0.0004302871,0.001742827,0.004938726,0.000426226,0.00004168635,0.003713165,0.00001680291,0.0000255931,0.0001172987,0.005051464,0.9831163],"study_design_scores_gemma":[0.003523448,0.00002676489,0.00009579451,0.001653316,0.000468096,0.00003410786,0.0004329529,0.0009441138,0.000175505,0.000007077446,0.9919727,0.0006660759],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1742961,0.8212129,0.000005731083,0.0002181661,0.001271963,0.002631708,0.00005542137,0.00005987301,0.0002481819],"genre_scores_gemma":[0.06293861,0.934737,0.0002384282,0.0003108175,0.0006706909,0.0003752359,0.0003485285,0.00005155321,0.0003291591],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9869213,"threshold_uncertainty_score":0.9996716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4238691881266975,"score_gpt":0.4698484026029256,"score_spread":0.04597921447622805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}