{"id":"W2097932685","doi":"10.1091/mbc.e15-04-0232","title":"A complex of ZO-1 and the BAR-domain protein TOCA-1 regulates actin assembly at the tight junction","year":2015,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"NHLBI Division of Intramural Research; National Heart, Lung, and Blood Institute; Instytut Biologii Medycznej Polskiej Akademii Nauk; University of North Carolina at Chapel Hill; National Institutes of Health; Queen's University","keywords":"PDZ domain; Adherens junction; Cell biology; Tight junction; Biology; Actin cytoskeleton; Claudin; Actin; Occludin; Cytoskeleton; Cell junction; Paracellular transport; Cadherin; Cell; Biochemistry; Membrane","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003878982,0.0001158011,0.0001949926,0.00002169775,0.000207919,0.000007656456,0.0002784899,0.00006977763,0.00002083945],"category_scores_gemma":[0.0002309041,0.0000487475,0.0000880908,0.0001418831,0.001284461,0.0000171558,0.00032198,0.0001154046,0.000004425079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001212728,"about_ca_system_score_gemma":0.00002025159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002730333,"about_ca_topic_score_gemma":0.0000145292,"domain_scores_codex":[0.9986994,0.0006352271,0.0001848603,0.000212703,0.0001288074,0.000139004],"domain_scores_gemma":[0.9991964,0.0001217016,0.0002087851,0.0003971654,0.00004978874,0.00002619699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003392973,0.00001017322,0.0000956312,0.00000787549,0.00001570608,6.696521e-7,0.0003545062,0.000008518218,0.9940511,0.00342684,0.001480714,0.0002089619],"study_design_scores_gemma":[0.000804638,0.0001800055,0.0005872941,0.000004900247,0.00002762763,0.00001857203,0.000193351,0.00004421655,0.9806024,0.008186819,0.009291154,0.00005896409],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895442,0.0005260051,0.0003549434,0.005083636,0.0002596073,0.000478132,0.000007107317,0.00001081794,0.003735591],"genre_scores_gemma":[0.9982589,0.000009743809,0.000102167,0.0006221418,0.00002059455,0.00002203617,0.000001058205,0.000007422112,0.0009559311],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01344865,"threshold_uncertainty_score":0.473265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02434487778405955,"score_gpt":0.2462293514605177,"score_spread":0.2218844736764582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}