{"id":"W2097956157","doi":"10.3389/fphar.2015.00260","title":"Study of GABA in Healthy Volunteers: Pharmacokinetics and Pharmacodynamics","year":2015,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; University of Toronto","funders":"Huashan Hospital; National Natural Science Foundation of China; Juvenile Diabetes Research Foundation International","keywords":"Pharmacokinetics; Medicine; Dosing; Pharmacodynamics; Placebo; Internal medicine; Oral administration; Adverse effect; Pharmacology; Endocrinology; Glucagon; Insulin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006791801,0.0006850104,0.001126518,0.0002233936,0.0003637766,0.0003238744,0.0001983625,0.0007342968,0.001145788],"category_scores_gemma":[0.0008417267,0.0003036802,0.0003063286,0.0002163063,0.0003661559,0.0002689519,0.0001975045,0.0007244145,0.0004694437],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001756899,"about_ca_system_score_gemma":0.0003211131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005333084,"about_ca_topic_score_gemma":0.0006276338,"domain_scores_codex":[0.9996215,0.000141639,0.00003145808,0.0001004897,0.00006469458,0.00004015752],"domain_scores_gemma":[0.9995752,0.00007587053,0.0000795381,0.00005066373,0.00006484631,0.0001539613],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2843546,0.01522752,0.1352109,0.0008202119,0.001138759,0.002241926,0.00104229,0.001001298,0.415395,0.0002493998,0.002128467,0.1411896],"study_design_scores_gemma":[0.009797284,0.4706191,0.4649048,0.00005159593,0.0009541606,0.003579866,0.000446665,0.002732888,0.03958399,0.0003466487,0.0068936,0.00008954335],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957677,0.001847949,0.0009948553,0.00006761452,0.00004481296,0.0003176716,0.0002320049,0.00007712348,0.0006502583],"genre_scores_gemma":[0.9957302,0.0007255626,0.001338665,0.0003223785,0.0000700623,0.0004318007,0.0003776848,0.00002103008,0.0009825478],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001145788,"threshold_uncertainty_score":0.003832996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07617315682091962,"score_gpt":0.3914460739372601,"score_spread":0.3152729171163404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}