{"id":"W2097956157","doi":"10.3389/fphar.2015.00260","title":"Study of GABA in Healthy Volunteers: Pharmacokinetics and Pharmacodynamics","year":2015,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; University of Toronto","funders":"Huashan Hospital; National Natural Science Foundation of China; Juvenile Diabetes Research Foundation International","keywords":"Pharmacokinetics; Medicine; Dosing; Pharmacodynamics; Placebo; Internal medicine; Oral administration; Adverse effect; Pharmacology; Endocrinology; Glucagon; Insulin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008678303,0.0002698878,0.0005433693,0.00113028,0.00007063135,0.00001814805,0.000690315,0.0000942518,0.00003334756],"category_scores_gemma":[0.0002336599,0.0002829563,0.00003421398,0.001595332,0.0006273894,0.0003147191,0.0003728817,0.0008743048,0.000008492164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001573321,"about_ca_system_score_gemma":0.000224932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004571999,"about_ca_topic_score_gemma":0.00002712707,"domain_scores_codex":[0.9960639,0.001081344,0.0006606155,0.0008791469,0.0004806575,0.0008343691],"domain_scores_gemma":[0.9989725,0.0002733881,0.0001471111,0.0001851118,0.00006392291,0.0003579103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00433246,0.0043742,0.1555303,0.00006589894,0.00001739295,0.002213809,0.003969016,0.002306967,0.8081344,0.00003344157,0.01597131,0.003050854],"study_design_scores_gemma":[0.07703382,0.0116368,0.01057385,0.00003251269,0.0001731512,0.0004084545,0.008050066,0.1815161,0.6975929,0.000713825,0.01090271,0.001365866],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930946,0.0003167294,0.00005336845,0.0006272026,0.004229254,0.001281311,0.00001785457,0.00004235639,0.0003373706],"genre_scores_gemma":[0.9958014,0.001210766,0.0001155591,0.002551589,0.00008427333,0.0001180674,4.491268e-7,0.00003351402,0.00008439451],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1792091,"threshold_uncertainty_score":0.9999623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07617315682091962,"score_gpt":0.3914460739372601,"score_spread":0.3152729171163404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}