{"id":"W2097966523","doi":"10.1093/hmg/ddl418","title":"Regulation of c-Ret in the developing kidney is responsive to Pax2 gene dosage","year":2006,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; American Society of Nephrology","keywords":"Biology; Glial cell line-derived neurotrophic factor; Kidney development; Proto-Oncogene Proteins c-ret; Receptor tyrosine kinase; Kidney; Endocrinology; Internal medicine; Ureteric bud; Gene expression; Receptor; Signal transduction; Cell biology; Gene; Embryonic stem cell; Genetics; Neurotrophic factors","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001745635,0.0004283021,0.0003605596,0.0005630318,0.0002387406,0.0004904671,0.0003073135,0.0004489939,0.002169883],"category_scores_gemma":[0.0002138666,0.0003752649,0.0002729552,0.0001911982,0.0004555445,0.000248227,0.0004903147,0.0006223788,0.0004739411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004683435,"about_ca_system_score_gemma":0.0003248054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006514349,"about_ca_topic_score_gemma":0.001093827,"domain_scores_codex":[0.9995638,0.00004370094,0.00004597709,0.0001322668,0.0001551006,0.0000591883],"domain_scores_gemma":[0.9996443,0.00006762859,0.0001165446,0.00004252099,0.00004276189,0.00008625988],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002185559,0.000003519712,0.0001336744,0.00001091915,0.000002155171,0.0000404659,0.000008095116,0.00003565794,0.9993415,0.0000842704,0.000008449922,0.000309484],"study_design_scores_gemma":[0.0000129036,0.00005660678,0.006529801,0.000006037618,0.00001567557,0.0003333584,0.00002953314,0.0007430135,0.9904283,0.00006427774,0.001773141,0.00000741547],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922777,0.001241159,0.003385669,0.00009812934,0.00003025127,0.0000266083,0.0005808503,0.0001917205,0.002167778],"genre_scores_gemma":[0.9910961,0.0007648807,0.002381608,0.00005724667,0.00001323814,0.00006594005,0.0006703175,0.0000916537,0.004859083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002169883,"threshold_uncertainty_score":0.007258952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00792558538328634,"score_gpt":0.2518160842102821,"score_spread":0.2438904988269958,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}