{"id":"W2097966523","doi":"10.1093/hmg/ddl418","title":"Regulation of c-Ret in the developing kidney is responsive to Pax2 gene dosage","year":2006,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; American Society of Nephrology","keywords":"Biology; Glial cell line-derived neurotrophic factor; Kidney development; Proto-Oncogene Proteins c-ret; Receptor tyrosine kinase; Kidney; Endocrinology; Internal medicine; Ureteric bud; Gene expression; Receptor; Signal transduction; Cell biology; Gene; Embryonic stem cell; Genetics; Neurotrophic factors","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000169603,0.0001399398,0.0001203887,0.00008156898,0.00006175705,0.00001700941,0.0002452915,0.0001508063,0.00000947501],"category_scores_gemma":[0.00002555058,0.0001151945,0.00007730681,0.0002211114,0.00006194863,0.000001403496,0.00007079661,0.00007989674,0.00000512666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002253757,"about_ca_system_score_gemma":0.0001019483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005089716,"about_ca_topic_score_gemma":0.00003074612,"domain_scores_codex":[0.9989274,0.0001066159,0.0002834969,0.0002718355,0.0002043287,0.0002063588],"domain_scores_gemma":[0.9993861,0.000005536308,0.00008682327,0.0003841353,0.00009030562,0.00004704784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000034773,0.00001821413,0.0004445068,0.00001266111,0.00002096008,0.0000104184,0.0001591021,0.001940448,0.9932126,0.0005565076,0.00334979,0.0002400466],"study_design_scores_gemma":[0.0003763477,0.0001590103,0.04031425,0.00003782195,0.00001972063,0.00001120543,0.0000383076,0.00002699408,0.9396334,0.001329892,0.01786606,0.0001870205],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930472,0.0009133889,0.003783895,0.0006593324,0.00004973802,0.0002592427,0.00001462211,0.00000433967,0.001268212],"genre_scores_gemma":[0.9949229,0.00008319929,0.002411747,0.002076357,0.00008695221,0.00001754645,0.0001087173,0.0000211378,0.0002714167],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0535792,"threshold_uncertainty_score":0.4697496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00792558538328634,"score_gpt":0.2518160842102821,"score_spread":0.2438904988269958,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}