{"id":"W2097998201","doi":"10.1158/2159-8290.cd-12-0464","title":"Primary Melanoma of the CNS in Children Is Driven by Congenital Expression of Oncogenic <i>NRAS</i> in Melanocytes","year":2013,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Cutaneous Melanoma Detection and Management","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"Cancer Research UK; Wellcome Trust","keywords":"Neuroblastoma RAS viral oncogene homolog; Melanoma; Cancer research; Biology; Melanocyte; Immunology; Medicine; Mutation; Genetics; Gene; KRAS","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001570568,0.0005554225,0.0002930734,0.0004279591,0.0002679908,0.0002369405,0.0002102039,0.000393251,0.001987645],"category_scores_gemma":[0.0001881568,0.0001694368,0.0002948503,0.0002355123,0.0005794532,0.000190769,0.0003312874,0.0006044682,0.0002951293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004312747,"about_ca_system_score_gemma":0.0003652171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001162934,"about_ca_topic_score_gemma":0.002142183,"domain_scores_codex":[0.9998507,0.00001729666,0.00001175713,0.00004421392,0.00003601378,0.0000399542],"domain_scores_gemma":[0.9996188,0.00006791694,0.0002119246,0.00002134018,0.00001973352,0.00006031033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003297425,0.00009555114,0.0371552,0.0002571343,0.00004694609,0.03136493,0.0001545647,0.00040757,0.9203274,0.0007605465,0.0005589951,0.008541429],"study_design_scores_gemma":[0.00005577866,0.001236715,0.13926,0.00008438792,0.0001424058,0.2471777,0.0003112749,0.001004174,0.6038053,0.0002643281,0.006629144,0.00002878722],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939156,0.000791099,0.00247814,0.0001065371,0.00001803032,0.00003985047,0.0003082687,0.0001612527,0.002181336],"genre_scores_gemma":[0.9961535,0.0007327697,0.00228464,0.00002951782,0.000007536931,0.00001719068,0.0001194235,0.00002196544,0.0006334106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001987645,"threshold_uncertainty_score":0.006649315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006031484321416971,"score_gpt":0.2216577525698628,"score_spread":0.2156262682484458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}