{"id":"W2097998201","doi":"10.1158/2159-8290.cd-12-0464","title":"Primary Melanoma of the CNS in Children Is Driven by Congenital Expression of Oncogenic <i>NRAS</i> in Melanocytes","year":2013,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Cutaneous Melanoma Detection and Management","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"Cancer Research UK; Wellcome Trust","keywords":"Neuroblastoma RAS viral oncogene homolog; Melanoma; Cancer research; Biology; Melanocyte; Immunology; Medicine; Mutation; Genetics; Gene; KRAS","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000500193,0.0001227763,0.0003009216,0.00009376545,0.00001578021,0.000009780644,0.0001388807,0.00006640379,0.0003620058],"category_scores_gemma":[0.0000117102,0.00008632944,0.0001062147,0.0002100085,0.00008568788,0.0001420725,0.0001156752,0.0001355403,0.000006359474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001679332,"about_ca_system_score_gemma":0.000100502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001309914,"about_ca_topic_score_gemma":0.0001535934,"domain_scores_codex":[0.9990382,0.00003607336,0.0003309596,0.0002049885,0.0002242772,0.0001655136],"domain_scores_gemma":[0.9994692,0.00002546344,0.0001415862,0.0002953892,0.00002857342,0.00003982868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001278682,0.0001968352,0.6141469,0.00008978627,0.00007244397,0.000003256113,0.0003386498,0.00002016898,0.3729024,0.000008859615,0.00820931,0.003883433],"study_design_scores_gemma":[0.001809749,0.0001236555,0.6152462,0.0002898286,0.00006003338,0.000018172,0.0001776927,0.00003052074,0.3812511,0.00003737699,0.0008336261,0.0001219884],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943541,0.001825029,0.000009301945,0.0003306759,0.0001476821,0.0007750919,0.00007256027,0.000008726204,0.002476797],"genre_scores_gemma":[0.9973359,0.0003779503,0.00002223699,0.0004971127,0.00003984383,0.00008973124,0.00001595675,0.00001591304,0.001605415],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008348675,"threshold_uncertainty_score":0.396371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006031484321416971,"score_gpt":0.2216577525698628,"score_spread":0.2156262682484458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}