{"id":"W2098052125","doi":"10.1016/j.ccr.2013.10.006","title":"Reduced H3K27me3 and DNA Hypomethylation Are Major Drivers of Gene Expression in K27M Mutant Pediatric High-Grade Gliomas","year":2013,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":842,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"National Institute of Neurological Disorders and Stroke; National Institutes of Health; Deutsche Krebshilfe; McKenna Claire Foundation; Deutsches Krebsforschungszentrum; Alex's Lemonade Stand Foundation for Childhood Cancer; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Bundesministerium für Bildung und Forschung; Cure Starts Now Foundation; St. Baldrick's Foundation","keywords":"Biology; Histone; Chromatin immunoprecipitation; Mutant; Epigenetics; Chromatin; EZH2; Methyltransferase; Histone H3; DNA methylation; PRC2; Gene; Genetics; Mutation; Gene expression; Methylation; Cell biology; Cancer research; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01245433326365663,"score_gpt":0.241097554619525,"score_spread":0.2286432213558683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}