{"id":"W2098052125","doi":"10.1016/j.ccr.2013.10.006","title":"Reduced H3K27me3 and DNA Hypomethylation Are Major Drivers of Gene Expression in K27M Mutant Pediatric High-Grade Gliomas","year":2013,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":842,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"National Institute of Neurological Disorders and Stroke; National Institutes of Health; Deutsche Krebshilfe; McKenna Claire Foundation; Deutsches Krebsforschungszentrum; Alex's Lemonade Stand Foundation for Childhood Cancer; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Bundesministerium für Bildung und Forschung; Cure Starts Now Foundation; St. Baldrick's Foundation","keywords":"Biology; Histone; Chromatin immunoprecipitation; Mutant; Epigenetics; Chromatin; EZH2; Methyltransferase; Histone H3; DNA methylation; PRC2; Gene; Genetics; Mutation; Gene expression; Methylation; Cell biology; Cancer research; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001181534,0.0002080727,0.000262528,0.0006980374,0.0001732599,0.0003663202,0.0002821995,0.0002029842,0.001253386],"category_scores_gemma":[0.0003260224,0.0002454907,0.00014435,0.0004878971,0.000248661,0.0002208385,0.0002292462,0.0002667995,0.0002212824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004381022,"about_ca_system_score_gemma":0.0003305121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00221383,"about_ca_topic_score_gemma":0.002753619,"domain_scores_codex":[0.9998559,0.00001214629,0.00001111162,0.00002796402,0.00005285951,0.0000400541],"domain_scores_gemma":[0.9997851,0.00002157982,0.000113519,0.00001379626,0.00002491392,0.00004116427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009446375,0.00003104016,0.0997278,0.00008978309,0.00004636939,0.001148345,0.0001340819,0.000434417,0.8851566,0.0003634004,0.0003170169,0.01160655],"study_design_scores_gemma":[0.00001737329,0.0001651466,0.5552301,0.000007447351,0.00006771401,0.007055569,0.0004044485,0.001067757,0.4332812,0.0002803729,0.002410355,0.00001258057],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979305,0.0004770954,0.0007512069,0.00003355078,0.00000268095,0.000004597292,0.0003238664,0.00004730362,0.0004290549],"genre_scores_gemma":[0.9987761,0.0002670501,0.0003814273,0.000007125683,0.000002031759,0.000004611942,0.0002524238,0.00001412554,0.0002949907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00221383,"threshold_uncertainty_score":0.004401922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01245433326365663,"score_gpt":0.241097554619525,"score_spread":0.2286432213558683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}