{"id":"W2098119888","doi":"10.1586/erm.12.39","title":"Epigenetic biomarkers in colorectal cancer diagnostics","year":2012,"lang":"en","type":"review","venue":"Expert Review of Molecular Diagnostics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"","keywords":"Epigenetics; Colorectal cancer; DNA methylation; Biomarker; Medicine; microRNA; Biomarker discovery; Bioinformatics; Cancer; Histone; Genome instability; Oncology; Internal medicine; Biology; Proteomics; DNA damage; Gene expression; Gene; Genetics; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006663554,0.0007738863,0.002025248,0.0002119262,0.00004032265,0.00001791279,0.0006273882,0.0007063526,0.00008107301],"category_scores_gemma":[0.002072014,0.0007109102,0.0008328385,0.0005383617,0.0001683635,0.000004705572,0.0003341143,0.0003065566,0.00002397954],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001024963,"about_ca_system_score_gemma":0.0005075355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000618882,"about_ca_topic_score_gemma":0.00003717521,"domain_scores_codex":[0.9960669,0.0006053764,0.001522477,0.0007356142,0.0004413213,0.0006283105],"domain_scores_gemma":[0.9975308,0.0003762902,0.0008339136,0.0008018786,0.0002156992,0.0002413931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000005981993,0.0002875855,0.0002273564,0.0491068,0.0004814538,0.00003514676,0.00002130371,0.00000456026,0.001717384,0.00003703725,0.001752653,0.9463227],"study_design_scores_gemma":[0.0001928942,0.0001488297,0.00004196523,0.06006698,0.0008361865,0.000007584274,0.000003121854,0.00000105369,0.01095506,0.00001292747,0.9270164,0.0007169373],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001150114,0.9962735,0.0005284742,0.00004161306,0.0007532581,0.00183343,0.000188257,0.00001054046,0.0002559637],"genre_scores_gemma":[0.0001077528,0.9958074,0.001219271,0.0002436971,0.0004124028,0.0008707692,0.001159516,0.0001680687,0.00001110287],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9456058,"threshold_uncertainty_score":0.9995342,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02463974196940952,"score_gpt":0.3617288068919508,"score_spread":0.3370890649225413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}