{"id":"W2098134263","doi":"10.1124/mol.59.6.1446","title":"Key Structural Features of Prostaglandin E<sub>2</sub>and Prostanoid Analogs Involved in Binding and Activation of the Human EP<sub>1</sub>Prostanoid Receptor","year":2001,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Prostanoid; Agonist; Potency; Chemistry; Receptor; Radioligand; Prostaglandin; Stereochemistry; Partial agonist; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008531933,0.0002571351,0.0002205418,0.0001221767,0.00018603,0.0001381826,0.0003284587,0.0002689825,0.007700208],"category_scores_gemma":[0.0001480608,0.0001342703,0.0002140699,0.00009145989,0.0001781987,0.0002008364,0.0000917681,0.000314191,0.0007729155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003454336,"about_ca_system_score_gemma":0.0002229044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008926339,"about_ca_topic_score_gemma":0.0007660858,"domain_scores_codex":[0.9999431,0.00001274988,0.000002841434,0.000007737693,0.00001247293,0.00002101575],"domain_scores_gemma":[0.9999471,0.00001941229,0.00001312038,0.000005099711,0.000004299088,0.00001104785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001810701,0.0001044118,0.0006124995,0.00007906322,0.00001614244,0.001023608,0.00004465058,0.001661509,0.9825466,0.004086457,0.0003811051,0.007633246],"study_design_scores_gemma":[0.0002137093,0.001408477,0.01015504,0.00001331039,0.00004785045,0.002696136,0.00009197513,0.005150651,0.9679933,0.001241244,0.01095838,0.00002993363],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830724,0.001976126,0.004957867,0.0002840157,0.00006777653,0.00008834846,0.0005519991,0.00005140622,0.008950151],"genre_scores_gemma":[0.9905144,0.0009757751,0.002171165,0.0001790997,0.00002982009,0.0000416074,0.0008951764,0.000009440467,0.005183449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007700208,"threshold_uncertainty_score":0.02575976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008075821480597819,"score_gpt":0.2626580081013247,"score_spread":0.2545821866207268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}