{"id":"W2098143217","doi":"10.1126/stke.3812007pe14","title":"Metabolic Targeting as an Anticancer Strategy: Dawn of a New Era?","year":2007,"lang":"en","type":"article","venue":"Science s STKE","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":129,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research","funders":"","keywords":"Citric acid cycle; Pyruvate dehydrogenase complex; Pyruvate dehydrogenase kinase; Glycolysis; Warburg effect; Pyruvate kinase; Mitochondrion; Adenosine triphosphate; Anaerobic glycolysis; Biochemistry; Cell biology; Pyruvate decarboxylation; Biology; Chemistry; Metabolism; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001012,0.0001291251,0.0001736006,0.0000940992,0.0001340398,0.00004126024,0.0004302623,0.00007212567,0.00006891842],"category_scores_gemma":[0.0001489343,0.000116587,0.00006624105,0.0004687709,0.0004366221,0.0000243674,0.00009411277,0.00008662671,0.000008023244],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008868237,"about_ca_system_score_gemma":0.0009708163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004550086,"about_ca_topic_score_gemma":0.0001842073,"domain_scores_codex":[0.9984725,0.0000172377,0.000232287,0.0004467506,0.0003532148,0.0004779765],"domain_scores_gemma":[0.999082,0.000005309321,0.0001046406,0.0003742192,0.0001621094,0.0002716635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003542564,0.0000309051,0.0004877191,0.000003966891,0.000008079684,5.474458e-7,0.000151815,0.00003080883,0.9627123,0.001804878,0.0005031782,0.03423033],"study_design_scores_gemma":[0.0003620894,0.0001617903,0.01599841,0.000005788562,0.00001857381,0.000007964515,0.0003329345,0.0000233334,0.8458894,0.0005235972,0.1364945,0.0001815284],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872661,0.004464734,0.00119649,0.00004164286,0.0009036649,0.0001189009,0.00000795205,0.0000119959,0.005988549],"genre_scores_gemma":[0.9942832,0.0005176347,0.002590992,0.0002418837,0.001432125,0.000002048266,0.000009752603,0.00001226702,0.0009100972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1359913,"threshold_uncertainty_score":0.4754279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01371371231239895,"score_gpt":0.3098262898506976,"score_spread":0.2961125775382987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}