{"id":"W2098153346","doi":"10.1124/dmd.112.045245","title":"Down-Regulation of Hepatic CYP3A and CYP2C Mediated Metabolism in Rats with Moderate Chronic Kidney Disease","year":2012,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":62,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Metabolism; CYP3A; Kidney disease; Kidney; Biology; Internal medicine; Endocrinology; Pharmacology; Chemistry; Medicine; Cytochrome P450","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000311425,0.0005801852,0.001002794,0.0007671454,0.0005335906,0.0004691688,0.0003208077,0.0004586015,0.002204419],"category_scores_gemma":[0.0003222088,0.0003512135,0.0008233202,0.0004921216,0.0008157744,0.0004720879,0.0003831984,0.001378109,0.0002894662],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005559024,"about_ca_system_score_gemma":0.0007644836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003371129,"about_ca_topic_score_gemma":0.004742604,"domain_scores_codex":[0.9996679,0.00003753848,0.00003160171,0.00007036117,0.00006007907,0.0001325776],"domain_scores_gemma":[0.999507,0.00004479793,0.0001207076,0.00007381134,0.00005611592,0.0001976213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01901377,0.001240695,0.003100523,0.0001062801,0.00007474615,0.0003074058,0.0001019105,0.0001879238,0.9703556,0.0002659546,0.0001563513,0.005088789],"study_design_scores_gemma":[0.000810598,0.009849472,0.05601453,0.00001791425,0.0003490043,0.0006670692,0.0004125775,0.002135247,0.9265708,0.0003386684,0.002769331,0.00006465273],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998492,0.0003011566,0.0006368527,0.00009772668,0.00003990554,0.00001691111,0.0001624937,0.00004397965,0.0002088509],"genre_scores_gemma":[0.996586,0.0003670364,0.0006248581,0.0000612471,0.0000211322,0.00006031423,0.0003613264,0.0000205025,0.001897604],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003371129,"threshold_uncertainty_score":0.007374525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02481387287060385,"score_gpt":0.3289415964829721,"score_spread":0.3041277236123682,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}